Drug Information

Drug General Information
Drug ID
D07XLJ
Former ID
DNC004818
Drug Name
N*6*-Benzyl-quinazoline-2,4,6-triamine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527455]
Formula
C15H15N5
Canonical SMILES
C1=CC=C(C=C1)CNC2=CC3=C(C=C2)N=C(N=C3N)N
InChI
1S/C15H15N5/c16-14-12-8-11(6-7-13(12)19-15(17)20-14)18-9-10-4-2-1-3-5-10/h1-8,18H,9H2,(H4,16,17,19,20)
InChIKey
PTWJNRZKGULCMJ-UHFFFAOYSA-N
PubChem Compound ID
462120
Target and Pathway
Target(s) Dihydrofolate reductase Target Info Inhibitor [527455]
PathWhiz Pathway Folate Metabolism
Pterine Biosynthesis
Reactome E2F mediated regulation of DNA replication
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Metabolism of folate and pterines
G1/S-Specific Transcription
References
Ref 527455J Med Chem. 2005 Mar 10;48(5):1448-69.CoMFA and CoMSIA analyses of Pneumocystis carinii dihydrofolate reductase, Toxoplasma gondii dihydrofolate reductase, and rat liver dihydrofolate reductase.
Ref 527455J Med Chem. 2005 Mar 10;48(5):1448-69.CoMFA and CoMSIA analyses of Pneumocystis carinii dihydrofolate reductase, Toxoplasma gondii dihydrofolate reductase, and rat liver dihydrofolate reductase.