Drug General Information
Drug ID
D08PMB
Former ID
DIB006278
Drug Name
Imeglimin
Drug Type
Small molecular drug
Indication Type 2 diabetes [ICD9: 250; ICD10:E11] Phase 2 [524449]
Company
Merck KGaA
Formula
C6H13N5
Canonical SMILES
N1=C(N[C@@H](N=C1N)C)N(C)C
CAS Number
CAS 775351-65-0
PubChem Compound ID
Target and Pathway
Target(s) AMP-activated protein kinase Target Info Modulator [549117]
KEGG Pathway FoxO signaling pathway
Regulation of autophagy
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Circadian rhythm
Insulin signaling pathway
Adipocytokine signaling pathway
Oxytocin signaling pathway
Glucagon signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Hypertrophic cardiomyopathy (HCM)
Reactome Translocation of GLUT4 to the plasma membrane
Macroautophagy
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
TP53 Regulates Metabolic Genes
WikiPathways Insulin Signaling
Energy dependent regulation of mTOR by LKB1-AMPK
JAK/STAT
BDNF signaling pathway
Leptin signaling pathway
SREBF and miR33 in cholesterol and lipid homeostasis
SREBP signalling
Signaling by Insulin receptor
TOR Signaling
AMPK Signaling
References
Ref 524449ClinicalTrials.gov (NCT01951235) A Study of the Efficacy and Safety of 4 Doses of Imeglimin After 24 Weeks of Treatment in Subjects With Type 2 Diabetes. U.S. National Institutes of Health.
Ref 549117Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800032542)