Drug Information

Drug General Information
Drug ID
D08UDY
Former ID
DNC012462
Drug Name
1',2',3',6'-Tetrahydro-[2,4']bipyridinyl
Drug Type
Small molecular drug
Indication Discovery agent Investigative [533509]
Formula
C10H12N2
Canonical SMILES
C1CNCC=C1C2=CC=CC=N2
InChI
1S/C10H12N2/c1-2-6-12-10(3-1)9-4-7-11-8-5-9/h1-4,6,11H,5,7-8H2
InChIKey
IVRPDZRVHKIBBG-UHFFFAOYSA-N
PubChem Compound ID
15166842
Target and Pathway
Target(s) Alpha-1A adrenergic receptor Target Info Inhibitor [533509]
Alpha-1D adrenergic receptor Target Info Inhibitor [533509]
Alpha-2B adrenergic receptor Target Info Inhibitor [533509]
Alpha-2A adrenergic receptor Target Info Inhibitor [533509]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
AMPK signaling pathway
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretionhsa04020:Calcium signaling pathway
Salivary secretionhsa04022:cGMP-PKG signaling pathway
Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling eventsR-HSA-390696:Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
G alpha (i) signalling events
G alpha (z) signalling eventsR-HSA-390696:Adrenoceptors
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (z) signalling events
Surfactant metabolism
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Endothelin Pathways
GPCR ligand binding
GPCR downstream signaling
AMPK SignalingWP58:Monoamine GPCRs
GPCRs, OtherWP58:Monoamine GPCRs
Platelet Aggregation (Plug Formation)
GPCR downstream signalingWP58:Monoamine GPCRs
Integration of energy metabolism
References
Ref 533509J Med Chem. 1984 Sep;27(9):1182-5.Adrenoceptor and tetrabenazine antagonism activities of some pyridinyltetrahydropyridines.
Ref 533509J Med Chem. 1984 Sep;27(9):1182-5.Adrenoceptor and tetrabenazine antagonism activities of some pyridinyltetrahydropyridines.