TTD | Drug: D09DBY

Drug General Information
Drug ID	D09DBY
Former ID	DCL000961
Drug Name	Rilonacept
Synonyms	Rilonacept (USAN/INN)
Indication	Arthritis [ICD9: 710-719; ICD10:M00-M25]		Approved	[529941], [541871]
Indication	Acute gout flare [ICD9: 274; ICD10:M10]		Phase 3	[537207], [541871]
Company	Regeneron
CAS Number	CAS 501081-76-1
PubChem Substance ID	47208286
SuperDrug ATC ID	L04AC04
Target and Pathway
Target(s)	Interleukin-1 beta	Target Info	Modulator	[529941]
KEGG Pathway	MAPK signaling pathway
	Cytokine-cytokine receptor interaction
	NF-kappa B signaling pathway
	Apoptosis
	Osteoclast differentiation
	Toll-like receptor signaling pathway
	NOD-like receptor signaling pathway
	Cytosolic DNA-sensing pathway
	Hematopoietic cell lineage
	TNF signaling pathway
	Inflammatory mediator regulation of TRP channels
	Non-alcoholic fatty liver disease (NAFLD)
	Type I diabetes mellitus
	Alzheimer's disease
	Prion diseases
	Salmonella infection
	Pertussis
	Legionellosis
	Leishmaniasis
	Chagas disease (American trypanosomiasis)
	African trypanosomiasis
	Malaria
	Amoebiasis
	Tuberculosis
	Measles
	Influenza A
	Herpes simplex infection
	Inflammatory bowel disease (IBD)
	Rheumatoid arthritis
	Graft-versus-host disease
NetPath Pathway	Leptin Signaling Pathway
	IL5 Signaling Pathway
	IL1 Signaling Pathway
	IL2 Signaling Pathway
	IL3 Signaling Pathway
	TGF_beta_Receptor Signaling Pathway
	Wnt Signaling Pathway
	TCR Signaling Pathway
	TNFalpha Signaling Pathway
Pathway Interaction Database	IL27-mediated signaling events
	IL12-mediated signaling events
	IL1-mediated signaling events
	IFN-gamma pathway
	IL23-mediated signaling events
	Cellular roles of Anthrax toxin
Reactome	Interleukin-1 signaling
	Interleukin-1 processing
	CLEC7A/inflammasome pathway
WikiPathways	Toll-like receptor signaling pathway
	Monoamine Transport
	SIDS Susceptibility Pathways
	TCR Signaling Pathway
	Type II interferon signaling (IFNG)
	Senescence and Autophagy in Cancer
	Cytokines and Inflammatory Response
	MAPK Signaling Pathway
	Myometrial Relaxation and Contraction Pathways
	Aryl Hydrocarbon Receptor Pathway
	IL1 and megakaryotyces in obesity
	Hematopoietic Stem Cell Differentiation
	Spinal Cord Injury
	Allograft Rejection
	Alzheimers Disease
	Leptin signaling pathway
	IL-1 signaling pathway
	Interleukin-1 signaling
	Folate Metabolism
	Vitamin B12 Metabolism
	Selenium Micronutrient Network
	Serotonin Transporter Activity
	Regulation of toll-like receptor signaling pathway
	NOD pathway
References
Ref 529941	2008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6.
Ref 537207	New relief for gout. Nat Biotechnol. 2009 Apr;27(4):309-11.
Ref 541871	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6790).
Ref 529941	2008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6.

Drug Information