Drug Information

Drug General Information
Drug ID
D0A5FM
Former ID
DAP001056
Drug Name
Nitric Oxide
Synonyms
HNO; INOmax; Nitrosyl; Nitroxyl; Oxoazanyl; Stickmonoxyd; Stickstoffmonoxid; [NO]; Endogenous Nitrate Vasodilator; Mononitrogen monoxide; Monoxido de nitrogeno; Nitric oxide trimer; Nitrogen monooxide; Nitrogen monoxide; Nitrosyl hydride; Nitrosyl radical; Nitroxide radical; Oxido nitrico; Oxyde azotique; Oxyde nitrique [French]; Stickmonoxyd [German]; OHM 11771; Bioxyde d'azote; Bioxyde d'azote [French]; Endothelium-Derived Nitric Oxide; INOmax (TN); Monoxide, Mononitrogen; Monoxide, Nitrogen; Monoxyde d'azote; NITRIC-OXIDE; NO(); Nitrate Vasodilator, Endogenous; Nitric Oxide, Endothelium Derived; Nitric oxide (JAN); Nitric oxide 10% by volume or more; Nitric oxide, compressed [UN1660] [Poison gas]; Nitrogen oxide (NO); Oxide, Nitric; Oxido de nitrogeno(II); Oxidonitrogen(); Vasodilator, Endogenous Nitrate; Nitric Oxide, Endothelium-Derived; Nitrosyl hydride ((NO)H); Stickstoff(II)-oxid
Drug Type
Small molecular drug
Indication Respiratory failure [ICD9: 518.81; ICD10:J96] Approved [536500], [539631]
Cancer [ICD9: 140-229; ICD10:C00-C96] Phase 3 [539631], [551871]
Therapeutic Class
Bronchodilator Agents
Formula
NO
CAS Number
CAS 10102-43-9
PubChem Compound ID
145068
PubChem Substance ID
3009, 3815, 584758, 584760, 585304, 612541, 819430, 819437, 823106, 825225, 827786, 827830, 829083, 829196, 830346, 831905, 832739, 832741, 832746, 832749, 835684, 835924, 835946, 835951, 837432, 837589, 838043, 838516, 838735, 838738, 838741, 841103, 854516, 854518, 6435917, 6436059, 6436465, 7847142, 8009073, 8024763, 8025088, 10248789, 10322712, 10502255, 11532572, 11532575, 11533089, 11538857, 11538865, 14715948
ChEBI ID
ChEBI:16480
SuperDrug ATC ID
R07AX01
SuperDrug CAS ID
cas=010102439
Target and Pathway
Target(s) Guanylate cyclase Target Info Stimulator [537618]
References
Ref 536500Emerging therapies for treatment of acute lung injury and acute respiratory distress syndrome. Expert Opin Emerg Drugs. 2007 Sep;12(3):461-77.
Ref 539631(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2509).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 537618Nitric oxide and nitric oxide synthase isoforms in the normal, hypertrophic, and failing heart. Mol Cell Biochem. 2009 Jul 19.