TTD | Drug: D0A6DI

Drug General Information
Drug ID	D0A6DI
Former ID	DIB003993
Drug Name	RG-1662
Synonyms	GABA-A agonist (Alzheimer's disease), Roche
Indication	Alzheimer disease [ICD9: 331; ICD10:G30]		Phase 2	[525248]
Company	Roche Holding AG
Structure		Download 3D MOL
Target and Pathway
Target(s)	Gamma-aminobutyric-acid receptor alpha-5 subunit	Target Info	Agonist	[551418]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Retrograde endocannabinoid signaling
	GABAergic synapse
	Morphine addiction
	Nicotine addiction
Reactome	Ligand-gated ion channel transport
Reactome	GABA A receptor activation
WikiPathways	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
WikiPathways	Iron uptake and transport
References
Ref 525248	ClinicalTrials.gov (NCT02484703) A Study of RG1662 in Down Syndrome Among Children 6 to 11 Years of Age.
Ref 551418	RG1662, a Selective GABAA alpha5 Receptor Negative Allosteric Modulator, Increases Gamma Power in Young Adults with Down Syndrome. Neurology April 6, 2015 vol. 84 no. 14.

Drug Information