Drug Information

Drug General Information
Drug ID
D0BA5K
Former ID
DIB011008
Drug Name
Apaxifylline
Synonyms
BIIP-20; U-98950; BIIP-20-XX
Drug Type
Small molecular drug
Indication Cognitive disorders [ICD9: 290-294, 294.0, 780.09, 780.9, 780.93; ICD10:F01-F07, F04, F05, R41.3] Phase 2 [544358]
Company
Boehringer Ingelheim Corp
Formula
C16H22N4O3
Canonical SMILES
c12c(n(c(=O)n(c1=O)CCC)CCC)[nH]c(n2)C1CC(=O)CC1
CAS Number
CAS 151581-23-6
PubChem Compound ID
60949
Target and Pathway
Target(s) Adenosine A1 receptor Target Info Antagonist [545800]
KEGG Pathway cGMP-PKG signaling pathway
cAMP signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
Morphine addiction
NetPath Pathway TCR Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Adenosine P1 receptors
G alpha (i) signalling events
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 544358Xanthines as Adenosine Receptor Antagonists. Handb Exp Pharmacol. 2011; (200): 10.1007/978-3-642-13443-2_6.
Ref 545800Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004779)