Drug Information

Drug General Information
Drug ID
D0C7LY
Former ID
DNC008790
Drug Name
WAY-207024
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540952]
Formula
C30H32N6
InChI
InChI=1S/C30H32N6/c1-30(2,3)23-10-8-22(9-11-23)29-33-25-5-4-6-27(28(25)34-29)36-17-15-35(16-18-36)20-21-7-12-24-26(19-21)32-14-13-31-24/h4-14,19H,15-18,20H2,1-3H3,(H,33,34)
InChIKey
AVEVJMZJJJDOCI-UHFFFAOYSA-N
PubChem Compound ID
11496610
PubChem Substance ID
16598502, 23628984, 42575473, 77423529, 103611452, 104108198, 134345995, 137100374, 140738987, 140738989, 142959748, 172919872, 178102217, 229305680, 238322163, 243458814, 249375951
Target and Pathway
Target(s) Histamine H2 receptor Target Info Inhibitor [530005]
NK-2 receptor Target Info Inhibitor [530005]
Gonadotropin-releasing hormone receptor Target Info Inhibitor [530791]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gastric acid secretionhsa04020:Calcium signaling pathway
Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interaction
GnRH signaling pathway
NetPath Pathway IL1 Signaling Pathway
IL2 Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Histamine H2 receptor mediated signaling pathwayP00027:Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
PathWhiz Pathway Intracellular Signalling Through Histamine H2 Receptor and Histamine
Gastric Acid Production
Reactome Histamine receptors
G alpha (s) signalling eventsR-HSA-416476:G alpha (q) signalling eventsR-HSA-375281:Hormone ligand-binding receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Secretion of Hydrochloric Acid in Parietal Cells
GPCR ligand binding
GPCR downstream signalingWP2664:Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR downstream signaling
GPCRs, Other
References
Ref 540952(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5582).
Ref 530005J Med Chem. 2009 Apr 9;52(7):2148-52.Discovery of 6-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): an orally active antagonist of the gonadotropin releasing hormone receptor (GnRH-R).
Ref 530791Bioorg Med Chem Lett. 2010 Apr 15;20(8):2512-5. Epub 2010 Mar 3.Synthesis and biological evaluation of piperazinyl heterocyclic antagonists of the gonadotropin releasing hormone (GnRH) receptor.