TTD | Drug: D0C8UE

Drug General Information
Drug ID	D0C8UE
Former ID	DCL000077
Drug Name	Capridine-beta
Synonyms	Apremilast; CC 10004; Apremilast (USAN); CC-10004; N-[2-[1-(3-ethoxy-4-methoxy-phenyl)-2-methylsulfonyl-ethyl]-1,3-dioxo-isoindol-4-yl]acetamide
Drug Type	Small molecular drug
Indication	Psoriasis [ICD9: 696; ICD10:L40]		Discontinued in Phase 4	[533123]
Therapeutic Class	Anticancer Agents
Company	Gardant Pharma; Celgene
Structure		Download 3D MOL
Formula	C23H25NO7S
Canonical SMILES	CCOC1=C(C=CC(=C1)C(CS(=O)(=O)C)N2C(=O)C3=C(C2=O)C(=CC=C<br />3)CC(=O)C)OC
InChI	1S/C23H25NO7S/c1-5-31-20-12-15(9-10-19(20)30-3)18(13-32(4,28)29)24-22(26)17-8-6-7-16(11-14(2)25)21(17)23(24)27/h6-10,12,18H,5,11,13H2,1-4H3/t18-/m1/s1
InChIKey	MUKPBEDSDFRMNQ-GOSISDBHSA-N
CAS Number	CAS 608141-41-9
PubChem Compound ID	44153089
SuperDrug ATC ID	L04AA32
Target and Pathway
Target(s)	Cell division protein kinase 2	Target Info	Inhibitor	[551434]
	Cell division protein kinase 6	Target Info	Inhibitor	[551434]
	Cell division protein kinase 4	Target Info	Inhibitor	[551434]
	PDE4	Target Info	Inhibitor	[536085], [536370]
KEGG Pathway	FoxO signaling pathway
	Cell cycle
	Oocyte meiosis
	p53 signaling pathway
	PI3K-Akt signaling pathway
	Progesterone-mediated oocyte maturation
	Hepatitis B
	Measles
	Herpes simplex infection
	Epstein-Barr virus infection
	Pathways in cancer
	Viral carcinogenesis
	Prostate cancer
	Small cell lung cancerhsa04110:Cell cycle
	MicroRNAs in cancer
	Pancreatic cancer
	Glioma
	Melanoma
	Chronic myeloid leukemia
	Small cell lung cancer
	Non-small cell lung cancerhsa04110:Cell cycle
	Tight junction
	T cell receptor signaling pathway
	HTLV-I infection
	Bladder cancer
	Non-small cell lung cancer
NetPath Pathway	TCR Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling PathwayNetPath_11:TCR Signaling Pathway
	EGFR1 Signaling Pathway
	RANKL Signaling Pathway
PANTHER Pathway	p53 pathway
PANTHER Pathway	p53 pathway feedback loops 2
Pathway Interaction Database	Regulation of nuclear SMAD2/3 signaling
	Signaling events mediated by PRL
	p73 transcription factor network
	E2F transcription factor network
	ATR signaling pathway
	mTOR signaling pathway
	IL2-mediated signaling events
	FoxO family signaling
	FOXM1 transcription factor network
	BARD1 signaling events
	p53 pathway
	Regulation of retinoblastoma proteinp73pathway:p73 transcription factor network
	Coregulation of Androgen receptor activity
	C-MYB transcription factor network
	IL2 signaling events mediated by STAT5
	Regulation of retinoblastoma proteinsmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
	Validated targets of C-MYC transcriptional activation
	ATF-2 transcription factor network
	Regulation of retinoblastoma protein
Reactome	G0 and Early G1
	Activation of ATR in response to replication stress
	Regulation of APC/C activators between G1/S and early anaphase
	SCF(Skp2)-mediated degradation of p27/p21
	Senescence-Associated Secretory Phenotype (SASP)
	DNA Damage/Telomere Stress Induced Senescence
	Processing of DNA double-strand break ends
	G2 Phase
	Orc1 removal from chromatin
	Cyclin E associated events during G1/S transition
	Cyclin A/B1 associated events during G2/M transition
	p53-Dependent G1 DNA Damage Response
	Cyclin A:Cdk2-associated events at S phase entry
	Meiotic recombination
	Factors involved in megakaryocyte development and platelet productionR-HSA-2559580:Oxidative Stress Induced Senescence
	Oncogene Induced Senescence
	Cyclin D associated events in G1R-HSA-2559580:Oxidative Stress Induced Senescence
	RMTs methylate histone arginines
	Transcriptional regulation of white adipocyte differentiation
	Ubiquitin-dependent degradation of Cyclin D1
	Cyclin D associated events in G1
WikiPathways	DNA Damage Response
	ID signaling pathway
	DNA Replication
	G1 to S cell cycle control
	M/G1 Transition
	S Phase
	Meiotic Recombination
	Aryl Hydrocarbon Receptor
	ATM Signaling Pathway
	Retinoblastoma (RB) in Cancer
	Spinal Cord Injury
	Integrated Pancreatic Cancer Pathway
	Oncostatin M Signaling Pathway
	Prostate Cancer
	Signaling Pathways in Glioblastoma
	TSH signaling pathway
	Integrated Breast Cancer Pathway
	Integrated Cancer pathway
	Synthesis of DNA
	Regulation of DNA replication
	Mitotic G2-G2/M phases
	Mitotic G1-G1/S phases
	Factors involved in megakaryocyte development and platelet production
	Cell Cycle
	APC/C-mediated degradation of cell cycle proteins
	Cell Cycle Checkpoints
	miRNA Regulation of DNA Damage ResponseWP707:DNA Damage Response
	Wnt Signaling Pathway Netpath
	Metastatic brain tumor
	miR-targeted genes in muscle cell - TarBase
	miR-targeted genes in lymphocytes - TarBase
	miR-targeted genes in leukocytes - TarBase
	miR-targeted genes in epithelium - TarBase
	miRNAs involved in DNA damage response
	Ovarian Infertility Genes
	PPAR Alpha Pathway
	Bladder Cancer
	Transcriptional Regulation of White Adipocyte Differentiation
	miRNA Regulation of DNA Damage Response
References
Ref 533123	2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.
Ref 536085	CC-10004 . Curr Opin Investig Drugs. 2005 May;6(5):518-25.
Ref 536370	Highly selective phosphodiesterase 4 inhibitors for the treatment of allergic skin diseases and psoriasis. Inflamm Allergy Drug Targets. 2007 Mar;6(1):17-26.
Ref 551434	Agreement signed with Prostagenics to develop prostate cancer treatment. Innovate Oncology, Inc. 2005.

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