Drug Information

Drug General Information
Drug ID
D0D0XX
Former ID
DIB011792
Drug Name
LY-290154
Indication Asthma [ICD10:J45] Terminated [546276]
Company
Eli Lilly & Co
Canonical SMILES
n1(ccc2c1c(OCc1nnn[nH]1)ccc2)C(c1cc(/C=C/c2nc3cc(ccc3cc<br />2)Cl)ccc1)CCCc1nnn[nH]1
CAS Number
CAS 140639-61-8
Target and Pathway
Target(s) Cysteinyl leukotriene receptor 1 Target Info Modulator
Leukotriene CysLT2 receptor Target Info Modulator
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway TGF_beta_Receptor Signaling Pathway
IL4 Signaling Pathway
IL3 Signaling PathwayNetPath_16:IL4 Signaling Pathway
IL3 Signaling Pathway
Pathway Interaction Database Endothelinsendothelinpathway:Endothelins
Reactome Leukotriene receptors
G alpha (q) signalling eventsR-HSA-391906:Leukotriene receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
GPCR downstream signaling
References
Ref 546276Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007201)