Drug Information

Drug General Information
Drug ID
D0E0ZV
Former ID
DNC014312
Drug Name
3-(2-N-Piperidyl-acetamino)-rutaecarpine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530639]
Formula
C25H25N5O2
Canonical SMILES
C1CCN(CC1)CC(=O)NC2=CC3=C(C=C2)N=C4C5=C(CCN4C3=O)C6=CC=<br />CC=C6N5
InChI
1S/C25H25N5O2/c31-22(15-29-11-4-1-5-12-29)26-16-8-9-21-19(14-16)25(32)30-13-10-18-17-6-2-3-7-20(17)27-23(18)24(30)28-21/h2-3,6-9,14,27H,1,4-5,10-13,15H2,(H,26,31)
InChIKey
QCNQXHWYZYJQDL-UHFFFAOYSA-N
PubChem Compound ID
44624061
Target and Pathway
Target(s) Acetylcholinesterase Target Info Inhibitor [530639]
KEGG Pathway Glycerophospholipid metabolism
Cholinergic synapse
PANTHER Pathway Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
Nicotinic acetylcholine receptor signaling pathway
Pathway Interaction Database ATF-2 transcription factor network
PathWhiz Pathway Phospholipid Biosynthesis
WikiPathways Monoamine Transport
Biogenic Amine Synthesis
Acetylcholine Synthesis
Integrated Pancreatic Cancer Pathway
References
Ref 530639Eur J Med Chem. 2010 Apr;45(4):1415-23. Epub 2010 Jan 4.Synthesis and evaluation of novel rutaecarpine derivatives and related alkaloids derivatives as selective acetylcholinesterase inhibitors.
Ref 530639Eur J Med Chem. 2010 Apr;45(4):1415-23. Epub 2010 Jan 4.Synthesis and evaluation of novel rutaecarpine derivatives and related alkaloids derivatives as selective acetylcholinesterase inhibitors.