Drug General Information
Drug ID
D0E9HQ
Former ID
DCL000618
Drug Name
R7334
Synonyms
R 7334; 2-Nitro-6,7,8,9-tetrahydronaphtho(1,2-b)furan; 2-nitro-6,7,8,9-tetrahydrobenzo[g][1]benzofuran; 6,7,8,9-Tetrahydro-2-nitronaphtho(1,2-b)furan
Drug Type
Antibody
Indication Macular degeneration [ICD9: 362.5; ICD10:H35.3] Phase 1 [522356]
Company
Roche
Formula
C12H11NO3
Canonical SMILES
C1CCC2=C(C1)C=CC3=C2OC(=C3)[N+](=O)[O-]
InChI
1S/C12H11NO3/c14-13(15)11-7-9-6-5-8-3-1-2-4-10(8)12(9)16-11/h5-7H,1-4H2
InChIKey
DZLOYALXDCQGTA-UHFFFAOYSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Placenta growth factor Target Info [551607]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
PI3K-Akt signaling pathway
Focal adhesion
Pathways in cancer
NetPath Pathway TSH Signaling Pathway
Pathway Interaction Database VEGFR1 specific signals
Reactome VEGF ligand-receptor interactions
VEGF binds to VEGFR leading to receptor dimerization
WikiPathways Focal Adhesion
Signaling by VEGF
References
Ref 522356ClinicalTrials.gov (NCT00702494) Phase I Study on Monoclonal Antibody TB-403 Directed Against PlGF in Patients With Solid Tumours. U.S. National Institutes of Health.
Ref 551607Clinical pipeline report, company report or official report of Roche (2009).