Drug Information

Drug General Information
Drug ID
D0F3XT
Former ID
DNC002430
Drug Name
7,8-dihydrobiopterin
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551393]
Formula
C9H13N5O3
Canonical SMILES
CC(C(C1=NC2=C(NC1)NC(=NC2=O)N)O)O
InChI
1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3,6,15-16H,2H2,1H3,(H4,10,11,13,14,17)
InChIKey
FEMXZDUTFRTWPE-UHFFFAOYSA-N
CAS Number
CAS 6779-87-9
PubChem Compound ID
252
PubChem Substance ID
6577875, 6591724, 16885833, 24438629, 57320075, 79660988, 103115412, 104294295, 117589164, 125334785, 126406810, 126522970, 135611007, 137188633, 138546843, 162221352, 162894998, 184568073, 237616267
Target and Pathway
Target(s) Nitric oxide synthase, inducible Target Info Inhibitor [551393]
Dihydroneopterinaldolase Target Info Inhibitor [551393]
Tyrosine 3-monooxygenase Target Info Inhibitor [551393]
BioCyc Pathway Citrulline-nitric oxide cyclePWY66-301:Catecholamine biosynthesis
KEGG Pathway Arginine biosynthesis
Arginine and proline metabolism
Metabolic pathways
Calcium signaling pathway
HIF-1 signaling pathway
Peroxisome
Salmonella infection
Pertussis
Leishmaniasis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Tuberculosis
Pathways in cancer
Small cell lung cancerhsa00350:Tyrosine metabolism
Dopaminergic synapse
Prolactin signaling pathway
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Alcoholism
NetPath Pathway IL1 Signaling Pathway
IL2 Signaling Pathway
PANTHER Pathway Adrenaline and noradrenaline biosynthesis
Parkinson disease
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Pathway Interaction Database IL12-mediated signaling events
Alpha9 beta1 integrin signaling events
ATF-2 transcription factor network
IL23-mediated signaling events
Signaling mediated by p38-alpha and p38-beta
HIF-1-alpha transcription factor networkatf2_pathway:ATF-2 transcription factor network
AP-1 transcription factor network
p38 signaling mediated by MAPKAP kinases
Alpha-synuclein signaling
PathWhiz Pathway Catecholamine Biosynthesis
Reactome ROS production in response to bacteria
Nitric oxide stimulates guanylate cyclase
WikiPathways Type II interferon signaling (IFNG)
Spinal Cord Injury
AGE/RAGE pathway
Effects of Nitric OxideWP727:Monoamine Transport
SIDS Susceptibility Pathways
Biogenic Amine Synthesis
Dopaminergic Neurogenesis
Metabolism of amino acids and derivatives
Dopamine metabolism
Parkinsons Disease Pathway
Nicotine Activity on Dopaminergic Neurons
References
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.