Drug Information

Drug General Information
Drug ID
D0G1TY
Former ID
DCL000020
Drug Name
CPG 52364
Drug Type
Small molecular drug
Indication Systemic lupus erythematosus [ICD9: 710; ICD10:M32] Phase 1 [532501]
Company
Coley Pharma.
Formula
C24H32N6O2
Canonical SMILES
CN(C)CCNC1=NC(=NC2=CC(=C(C=C21)OC)OC)N3CCN(CC3)C4=CC=CC<br />=C4
InChI
1S/C24H32N6O2/c1-28(2)11-10-25-23-19-16-21(31-3)22(32-4)17-20(19)26-24(27-23)30-14-12-29(13-15-30)18-8-6-5-7-9-18/h5-9,16-17H,10-15H2,1-4H3,(H,25,26,27)
InChIKey
NRDOWTUUBQCUMC-UHFFFAOYSA-N
PubChem Compound ID
11774935
ChEBI ID
ChEBI:51098
Target and Pathway
Target(s) Toll-like receptor 7 Target Info Antagonist [551089]
Toll-like receptor 9 Target Info Antagonist [551089]
Toll-like receptor 8 Target Info Antagonist [551089]
KEGG Pathway Toll-like receptor signaling pathway
Measles
Influenza Ahsa04620:Toll-like receptor signaling pathway
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Malaria
Tuberculosis
Herpes simplex infectionhsa04620:Toll-like receptor signaling pathway
NetPath Pathway TCR Signaling PathwayNetPath_12:BCR Signaling PathwayNetPath_22:Leptin Signaling Pathway
TCR Signaling Pathway
PANTHER Pathway Toll receptor signaling pathwayP00054:Toll receptor signaling pathwayP00054:Toll receptor signaling pathway
Reactome Trafficking and processing of endosomal TLR
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 dependent cascade initiated on endosomeR-HSA-109704:PI3K Cascade
MyD88 dependent cascade initiated on endosomeR-HSA-1679131:Trafficking and processing of endosomal TLR
MyD88 dependent cascade initiated on endosome
WikiPathways Toll-like receptor signaling pathway
Toll-Like Receptors Cascades
MyD88 dependent cascade initiated on endosome
Trafficking and processing of endosomal TLR
Regulation of toll-like receptor signaling pathwayWP75:Toll-like receptor signaling pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Regulation of toll-like receptor signaling pathway
References
Ref 532501Treatment of systemic lupus erythematosus: new therapeutic avenues and blind alleys. Nat Rev Rheumatol. 2014 Jan;10(1):23-34.
Ref 551089Coley Pharmaceutical Group Diversifies Pipeline with First-in-Class TLR Antagonist for the Treatment of Systemic Lupus Erythematosus. Lupus Foundation of America, Inc. 2007.