Drug Information

Drug General Information
Drug ID
D0G2IC
Former ID
DNC005788
Drug Name
(S)-FLURBIPROFEN
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528008]
Formula
C15H13FO2
Canonical SMILES
CC(C1=CC(=C(C=C1)C2=CC=CC=C2)F)C(=O)O
InChI
1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)/t10-/m0/s1
InChIKey
SYTBZMRGLBWNTM-JTQLQIEISA-N
PubChem Compound ID
72099
Target and Pathway
Target(s) Gamma-secretase Target Info Inhibitor [528008]
Beta-secretase Target Info Inhibitor [528008]
Presenilin 2 Target Info Inhibitor [528008]
Prostaglandin G/H synthase 2 Target Info Inhibitor [527602]
Prostaglandin G/H synthase 1 Target Info Inhibitor [527602]
Presenilin 1 Target Info Inhibitor [528008]
BioCyc Pathway Aspirin-triggered lipoxin biosynthesis
Aspirin triggered resolvin D biosynthesis
C20 prostanoid biosynthesis
Aspirin triggered resolvin E biosynthesisPWY66-374:C20 prostanoid biosynthesis
KEGG Pathway Notch signaling pathway
Alzheimer's diseasehsa04330:Notch signaling pathway
Neurotrophin signaling pathway
Alzheimer's diseasehsa00590:Arachidonic acid metabolism
Metabolic pathways
NF-kappa B signaling pathway
VEGF signaling pathway
TNF signaling pathway
Retrograde endocannabinoid signaling
Serotonergic synapse
Ovarian steroidogenesis
Oxytocin signaling pathway
Regulation of lipolysis in adipocytes
Leishmaniasis
Pathways in cancer
Chemical carcinogenesis
MicroRNAs in cancer
Small cell lung cancerhsa00590:Arachidonic acid metabolism
Platelet activation
Serotonergic synapsehsa04310:Wnt signaling pathway
Alzheimer's disease
NetPath Pathway IL1 Signaling Pathway
TSH Signaling Pathway
IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
IL5 Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling PathwayNetPath_3:Notch Signaling Pathway
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Alzheimer disease-presenilin pathway
Notch signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
Notch signaling pathwayP00019:Endothelin signaling pathway
Inflammation mediated by chemokine and cytokine signaling pathway
Toll receptor signaling pathway
CCKR signaling map STP00031:Inflammation mediated by chemokine and cytokine signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
Notch signaling pathway
Pathway Interaction Database Notch signaling pathway
Presenilin action in Notch and Wnt signaling
p75(NTR)-mediated signaling
Syndecan-3-mediated signaling eventslkb1_pathway:LKB1 signaling eventsnfat_tfpathway:Calcineurin-regulated NFAT-dependent transcription in lymphocytes
S1P1 pathway
C-MYB transcription factor network
Signaling mediated by p38-alpha and p38-beta
Calcium signaling in the CD4+ TCR pathwaynotch_pathway:Notch signaling pathway
Syndecan-3-mediated signaling events
PathWhiz Pathway Arachidonic Acid MetabolismPW000044:Arachidonic Acid Metabolism
Reactome Nuclear signaling by ERBB4
Regulated proteolysis of p75NTR
NRIF signals cell death from the nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
NOTCH2 Activation and Transmission of Signal to the Nucleus
EPH-ephrin mediated repulsion of cellsR-HSA-1251985:Nuclear signaling by ERBB4
EPH-ephrin mediated repulsion of cellsR-HSA-1474228:Degradation of the extracellular matrix
WikiPathways Notch Signaling Pathway
Signaling by ERBB4
Signaling by NOTCH3
Signaling by NOTCH4
Signaling by NOTCH1
Signaling by NOTCH2
Notch Signaling Pathway
Signalling by NGFWP61:Notch Signaling Pathway
Alzheimers Disease
Signalling by NGFWP98:Prostaglandin Synthesis and Regulation
Arachidonic acid metabolism
Aryl Hydrocarbon Receptor
Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
Spinal Cord Injury
Integrated Pancreatic Cancer Pathway
Eicosanoid Synthesis
Selenium Micronutrient NetworkWP98:Prostaglandin Synthesis and Regulation
Phase 1 - Functionalization of compounds
Selenium Micronutrient NetworkWP61:Notch Signaling Pathway
References
Ref 528008Bioorg Med Chem Lett. 2006 Apr 15;16(8):2219-23. Epub 2006 Feb 7.The geminal dimethyl analogue of Flurbiprofen as a novel Abeta42 inhibitor and potential Alzheimer's disease modifying agent.
Ref 527602J Med Chem. 2005 Jun 30;48(13):4312-31.2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors.
Ref 528008Bioorg Med Chem Lett. 2006 Apr 15;16(8):2219-23. Epub 2006 Feb 7.The geminal dimethyl analogue of Flurbiprofen as a novel Abeta42 inhibitor and potential Alzheimer's disease modifying agent.