Drug General Information
Drug ID
D0G3ZH
Former ID
DNC009661
Drug Name
N-(quinolin-8-yl)-6-(sulfamoylamino)hexanamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529866]
Formula
C15H20N4O3S
Canonical SMILES
C1=CC2=C(C(=C1)NC(=O)CCCCCNS(=O)(=O)N)N=CC=C2
InChI
1S/C15H20N4O3S/c16-23(21,22)18-11-3-1-2-9-14(20)19-13-8-4-6-12-7-5-10-17-15(12)13/h4-8,10,18H,1-3,9,11H2,(H,19,20)(H2,16,21,22)
InChIKey
IQEBALPYRTUOEG-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) Histone deacetylase 6 Target Info Inhibitor [529866]
KEGG Pathway Alcoholism
Viral carcinogenesis
Pathway Interaction Database Signaling events mediated by HDAC Class II
Signaling events mediated by HDAC Class I
Reactome NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Assembly of the primary cilium
WikiPathways Ectoderm Differentiation
Neural Crest Differentiation
Cell Cycle
References
Ref 529866Bioorg Med Chem Lett. 2009 Jan 15;19(2):336-40. Epub 2008 Nov 27.Sulfamides as novel histone deacetylase inhibitors.
Ref 529866Bioorg Med Chem Lett. 2009 Jan 15;19(2):336-40. Epub 2008 Nov 27.Sulfamides as novel histone deacetylase inhibitors.