Drug Information

Drug General Information
Drug ID
D0G8UG
Former ID
DIB001922
Drug Name
Sulukast
Synonyms
LY-170680
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Discontinued in Phase 2 [540287], [544541]
Company
Eli Lilly & Co
Formula
C25H36N4O3S
InChI
InChI=1S/C25H36N4O3S/c1-2-3-4-5-6-7-8-9-10-11-12-16-22(33-18-17-23(30)31)24(32)20-14-13-15-21(19-20)25-26-28-29-27-25/h10-16,19,22,24,32H,2-9,17-18H2,1H3,(H,30,31)(H,26,27,28,29)/b11-10-,16-12+/t22-,24+/m1/s1
InChIKey
YPHOSUPSOWQQCB-AFOLHBCXSA-N
CAS Number
CAS 98116-53-1
PubChem Compound ID
6436123
PubChem Substance ID
12014330, 14858705, 17397007, 43029338, 50515662, 57367596, 103188239, 114550225, 135027709, 137263959, 178100360, 198963594, 226423378, 226423379
Target and Pathway
Target(s) Cysteinyl leukotriene receptor 1 Target Info Modulator
Leukotriene CysLT2 receptor Target Info Modulator
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway TGF_beta_Receptor Signaling Pathway
IL4 Signaling Pathway
IL3 Signaling PathwayNetPath_16:IL4 Signaling Pathway
IL3 Signaling Pathway
Pathway Interaction Database Endothelinsendothelinpathway:Endothelins
Reactome Leukotriene receptors
G alpha (q) signalling eventsR-HSA-391906:Leukotriene receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
GPCR downstream signaling
References
Ref 540287(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3327).
Ref 544541Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000090)