Drug Information

Drug General Information
Drug ID
D0HF4I
Former ID
DNC010832
Drug Name
4-(2-(4-Methoxyphenylamino)ethyl)-1H-imidazole
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530846]
Formula
C12H14N2OS
Canonical SMILES
COC1=CC=C(C=C1)SCCC2=CN=CN2
InChI
1S/C12H14N2OS/c1-15-11-2-4-12(5-3-11)16-7-6-10-8-13-9-14-10/h2-5,8-9H,6-7H2,1H3,(H,13,14)
InChIKey
MFQHSSADNRVZAE-UHFFFAOYSA-N
PubChem Compound ID
46888007
Target and Pathway
Target(s) Histamine H3 receptor Target Info Inhibitor [530846]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Histamine receptors
G alpha (i) signalling events
WikiPathways Monoamine Transport
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 530846J Med Chem. 2010 May 13;53(9):3840-4.Role of hydrophobic substituents on the terminal nitrogen of histamine in receptor binding and agonist activity: development of an orally active histamine type 3 receptor agonist and evaluation of its antistress activity in mice.
Ref 530846J Med Chem. 2010 May 13;53(9):3840-4.Role of hydrophobic substituents on the terminal nitrogen of histamine in receptor binding and agonist activity: development of an orally active histamine type 3 receptor agonist and evaluation of its antistress activity in mice.