Drug General Information
Drug ID
D0HP1O
Drug Name
AF-DX-384
Synonyms
AF-DX-384; 118290-27-0; AF-DX-384
Drug Type
Small molecular drug
Indication Unspecified Investigative [1560197], [1560396]
Formula
C27H38N6O2
PubChem Compound ID
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M4 Target Info Modulator
Muscarinic acetylcholine receptor M2 Target Info Modulator
KEGG Pathway Neuroactive ligand-receptor interaction
Cholinergic synapse
Regulation of actin cytoskeletonhsa04020:Calcium signaling pathway
cAMP signaling pathway
PI3K-Akt signaling pathway
Regulation of actin cytoskeleton
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
PathWhiz Pathway Muscle/Heart Contraction
Reactome Muscarinic acetylcholine receptors
G alpha (i) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
G alpha (i) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP706:SIDS Susceptibility Pathways
GPCR downstream signaling
GPCRs, Other
References
Ref 1560197M2 receptor binding of the selective antagonist AF-DX 384: possible involvement of the common allosteric site.
Ref 1560396M2/M4 muscarinic receptor binding in the anterior cingulate cortex in schizophrenia and mood disorders.