Drug Information

Drug General Information
Drug ID
D0J5RN
Former ID
DNCL003087
Drug Name
Armodafinil
Drug Type
Small molecular drug
Indication Pediatric cancer [ICD9: 140-229; ICD10:C00-C96] Approved [551871]
Company
Cephalon
Formula
C15H15NO2S
Canonical SMILES
C1=CC=C(C=C1)C(C2=CC=CC=C2)S(=O)CC(=O)N
InChI
1S/C15H15NO2S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H2,16,17)/t19-/m1/s1
InChIKey
YFGHCGITMMYXAQ-LJQANCHMSA-N
CAS Number
CAS 112111-43-0
PubChem Compound ID
9690109
PubChem Substance ID
12014108, 14824208, 17397368, 24099806, 44823274, 57373290, 58107158, 80296077, 103771175, 125086994, 134357052, 135200656, 136236020, 137001280, 137239495, 137624470, 152258644, 160647479, 162189556, 164230581, 175267253, 175270376, 186007031, 223443057, 223454698, 223519240, 226420943, 249797709, 251964004
SuperDrug ATC ID
N06BA07
Target and Pathway
Target(s) Alpha-1D adrenergic receptor Target Info Agonist [544068], [550911]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretion
NetPath Pathway IL2 Signaling Pathway
Reactome Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 544068Mechanisms of modafinil: A review of current research. Neuropsychiatr Dis Treat. 2007 June; 3(3): 349-364.
Ref 550911US patent application no. 2014,0349,964, Methods for inducing orexin neurons and agent for treating narcolepsy or eating disorder.