Drug Information

Drug General Information
Drug ID
D0J7RW
Former ID
DNC005282
Drug Name
WIN-55212-2
Drug Type
Small molecular drug
Indication Discovery agent Terminated [542353], [545702]
Formula
C27H26N2O3
InChI
InChI=1S/C27H26N2O3/c1-18-25(27(30)22-9-4-7-19-6-2-3-8-21(19)22)23-10-5-11-24-26(23)29(18)20(17-32-24)16-28-12-14-31-15-13-28/h2-11,20H,12-17H2,1H3/t20-/m1/s1
InChIKey
HQVHOQAKMCMIIM-HXUWFJFHSA-N
PubChem Compound ID
5311501
PubChem Substance ID
7980892, 11056544, 12014569, 14782868, 14929727, 26754855, 26754856, 39341166, 47647616, 48395014, 49681172, 49689353, 50110805, 50110806, 57359506, 77916044, 85787707, 90341664, 92309954, 99300867, 103513296, 124750377, 124881896, 124881897, 124881898, 124881899, 124881900, 124881901, 124881902, 128100013, 134342487, 135651326, 142472540, 162169305, 164766158, 179335180, 223591298, 226490429, 249967380, 252319849
Target and Pathway
Target(s) Cannabinoid receptor 1 Target Info Inhibitor [530009]
Cannabinoid receptor 2 Target Info Inhibitor [528907]
KEGG Pathway Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signalinghsa04080:Neuroactive ligand-receptor interaction
PANTHER Pathway Endogenous cannabinoid signaling
Pathway Interaction Database N-cadherin signaling events
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling eventsR-HSA-373076:Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
BDNF signaling pathway
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP455:GPCRs, Class A Rhodopsin-like
References
Ref 542353(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 733).
Ref 545702Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004262)
Ref 528907Eur J Med Chem. 2008 Mar;43(3):513-39. Epub 2007 May 6.Synthesis and cannabinoid activity of 1-substituted-indole-3-oxadiazole derivatives: novel agonists for the CB1 receptor.
Ref 530009Bioorg Med Chem. 2009 Apr 1;17(7):2842-51. Epub 2009 Feb 21.Synthesis and pharmacological evaluation of coumarin derivatives as cannabinoid receptor antagonists and inverse agonists.