Drug Information

Drug General Information
Drug ID
D0JD4C
Former ID
DNC005980
Drug Name
L-454560
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531102]
Formula
C31H29N3O5S2
Canonical SMILES
CC1=NOC(=N1)C(=CC2=CC=CC(=C2)C3=C4C(=CC(=C3)C(C)(C)S(=O<br />)(=O)C)C=CC=N4)C5=CC=C(C=C5)S(=O)(=O)C
InChI
1S/C31H29N3O5S2/c1-20-33-30(39-34-20)28(22-11-13-26(14-12-22)40(4,35)36)17-21-8-6-9-23(16-21)27-19-25(31(2,3)41(5,37)38)18-24-10-7-15-32-29(24)27/h6-19H,1-5H3/b28-17+
InChIKey
YYGZHVJDHMMABU-OGLMXYFKSA-N
PubChem Compound ID
9853498
Target and Pathway
Target(s) Type IV phosphodiesterase Target Info Inhibitor [531102]
CAMP-specific 3',5'-cyclic phosphodiesterase 4A Target Info Inhibitor [531102]
CAMP-specific 3',5'-cyclic phosphodiesterase 4B Target Info Inhibitor [531102]
KEGG Pathway Purine metabolism
cAMP signaling pathway
Morphine addictionhsa00230:Purine metabolism
Morphine addiction
NetPath Pathway IL5 Signaling Pathway
IL2 Signaling Pathway
PathWhiz Pathway Purine Metabolism
Reactome DARPP-32 events
G alpha (s) signalling eventsR-HSA-180024:DARPP-32 events
G alpha (s) signalling events
WikiPathways G Protein Signaling Pathways
Myometrial Relaxation and Contraction Pathways
TSH signaling pathwayWP35:G Protein Signaling PathwaysWP35:G Protein Signaling Pathways
Nuclear Receptors Meta-Pathway
Opioid Signalling
References
Ref 531102Bioorg Med Chem Lett. 2010 Sep 15;20(18):5502-5. Epub 2010 Jul 21.The discovery and synthesis of highly potent subtype selective phosphodiesterase 4D inhibitors.
Ref 531102Bioorg Med Chem Lett. 2010 Sep 15;20(18):5502-5. Epub 2010 Jul 21.The discovery and synthesis of highly potent subtype selective phosphodiesterase 4D inhibitors.