TTD | Drug: D0K2YG

Drug General Information
Drug ID	D0K2YG
Former ID	DNC011841
Drug Name	4-(5-Methoxy-benzoimidazol-1-yl)-phenylamine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[525530]
Formula	C14H13N3O
Canonical SMILES	COC1=CC2=C(C=C1)N(C=N2)C3=CC=C(C=C3)N
InChI	1S/C14H13N3O/c1-18-12-6-7-14-13(8-12)16-9-17(14)11-4-2-10(15)3-5-11/h2-9H,15H2,1H3
InChIKey	KLJLVCKIKCKKEA-UHFFFAOYSA-N
PubChem Compound ID	5328512
Target and Pathway
Target(s)	Alpha platelet-derived growth factor receptor	Target Info	Inhibitor	[525530]
Target(s)	Beta platelet-derived growth factor receptor	Target Info	Inhibitor	[525530]
KEGG Pathway	MAPK signaling pathway
	Ras signaling pathway
	Rap1 signaling pathway
	Calcium signaling pathway
	Cytokine-cytokine receptor interaction
	Endocytosis
	PI3K-Akt signaling pathway
	Focal adhesion
	Gap junction
	Regulation of actin cytoskeleton
	HTLV-I infection
	Pathways in cancer
	MicroRNAs in cancer
	Glioma
	Prostate cancer
	Melanoma
	Central carbon metabolism in cancer
	Choline metabolism in cancerhsa04010:MAPK signaling pathway
	Choline metabolism in cancer
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
PANTHER Pathway	Angiogenesis
	PDGF signaling pathwayP00005:Angiogenesis
	PDGF signaling pathway
Pathway Interaction Database	ATF-2 transcription factor network
	PDGFR-alpha signaling pathway
	PDGF receptor signaling networkptp1bpathway:Signaling events mediated by PTP1B
	Beta3 integrin cell surface interactions
	S1P3 pathway
	Nectin adhesion pathway
	Signaling events mediated by TCPTP
	SHP2 signaling
	S1P1 pathway
	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
	PDGFR-beta signaling pathway
	Validated targets of C-MYC transcriptional repression
	PDGF receptor signaling network
Reactome	PIP3 activates AKT signaling
	Constitutive Signaling by Aberrant PI3K in Cancer
	RAF/MAP kinase cascadeR-HSA-1257604:PIP3 activates AKT signaling
	RAF/MAP kinase cascade
WikiPathways	Regulation of Actin Cytoskeleton
	Osteoblast Signaling
	Focal Adhesion
	Hair Follicle Development: Organogenesis (Part 2 of 3)
	PIP3 activates AKT signaling
	Cardiac Progenitor Differentiation
	Integrated Pancreatic Cancer Pathway
	Allograft Rejection
	Signaling Pathways in Glioblastoma
	Signaling by PDGF
	AngiogenesisWP51:Regulation of Actin Cytoskeleton
	MAPK Signaling Pathway
	PDGF Pathway
References
Ref 525530	J Med Chem. 1999 Jul 1;42(13):2373-82.Structure-activity relationships for 5-substituted 1-phenylbenzimidazoles as selective inhibitors of the platelet-derived growth factor receptor.
Ref 525530	J Med Chem. 1999 Jul 1;42(13):2373-82.Structure-activity relationships for 5-substituted 1-phenylbenzimidazoles as selective inhibitors of the platelet-derived growth factor receptor.

Drug Information