Drug Information

Drug General Information
Drug ID
D0KH8S
Former ID
DNC007241
Drug Name
3-(6-morpholino-4-oxo-4H-pyran-2-yl)benzoic acid
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528738]
Formula
C16H15NO5
Canonical SMILES
C1COCCN1C2=CC(=O)C=C(O2)C3=CC(=CC=C3)C(=O)O
InChI
1S/C16H15NO5/c18-13-9-14(11-2-1-3-12(8-11)16(19)20)22-15(10-13)17-4-6-21-7-5-17/h1-3,8-10H,4-7H2,(H,19,20)
InChIKey
DIBMCWVULMJJDM-UHFFFAOYSA-N
PubChem Compound ID
16203474
Target and Pathway
Target(s) DNA-dependent protein kinase catalytic subunit Target Info Inhibitor [528738]
KEGG Pathway Non-homologous end-joining
Cell cycle
NetPath Pathway IL1 Signaling Pathway
Pathway Interaction Database DNA-PK pathway in nonhomologous end joining
Coregulation of Androgen receptor activity
Class I PI3K signaling events mediated by Akt
BARD1 signaling events
Reactome Nonhomologous End-Joining (NHEJ)
WikiPathways DNA Damage Response
Non-homologous end joining
FAS pathway and Stress induction of HSP regulation
Cytosolic sensors of pathogen-associated DNA
Retinoblastoma (RB) in Cancer
Prostate Cancer
Double-Strand Break Repair
Cell Cycle
miRNA Regulation of DNA Damage Response
References
Ref 528738J Med Chem. 2007 Apr 19;50(8):1958-72. Epub 2007 Mar 20.Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
Ref 528738J Med Chem. 2007 Apr 19;50(8):1958-72. Epub 2007 Mar 20.Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.