Drug Information

Drug General Information
Drug ID
D0KU5D
Former ID
DNC013864
Drug Name
YM-35278
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529738]
Formula
C38H30F2N4O3
Canonical SMILES
C1CN(C2=CC=CC=C2C(=CC(=O)NCC3=CC=CC=N3)C1(F)F)C(=O)C4=C<br />C=C(C=C4)NC(=O)C5=CC=CC=C5C6=CC=CC=C6
InChI
1S/C38H30F2N4O3/c39-38(40)21-23-44(34-16-7-6-15-32(34)33(38)24-35(45)42-25-29-12-8-9-22-41-29)37(47)27-17-19-28(20-18-27)43-36(46)31-14-5-4-13-30(31)26-10-2-1-3-11-26/h1-20,22,24H,21,23,25H2,(H,42,45)(H,43,46)/b33-24-
InChIKey
OPEZXZINWZCBQD-GIBOGKFOSA-N
PubChem Compound ID
44520886
Target and Pathway
Target(s) Vasopressin V2 receptor Target Info Inhibitor [529738]
KEGG Pathway Neuroactive ligand-receptor interaction
Vasopressin-regulated water reabsorption
Pathway Interaction Database Arf6 trafficking events
PathWhiz Pathway Vasopressin Regulation of Water Homeostasis
Reactome Vasopressin-like receptors
G alpha (s) signalling events
Vasopressin regulates renal water homeostasis via Aquaporins
WikiPathways GPCRs, Class A Rhodopsin-like
Regulation of Water Balance by Renal Aquaporins
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 529738Bioorg Med Chem. 2008 Nov 1;16(21):9524-35. Epub 2008 Sep 17.Preparation of (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene)acetamide derivatives as novel arginine vasopressin V(2) receptor agonists.
Ref 529738Bioorg Med Chem. 2008 Nov 1;16(21):9524-35. Epub 2008 Sep 17.Preparation of (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene)acetamide derivatives as novel arginine vasopressin V(2) receptor agonists.