Drug Information

Drug General Information
Drug ID
D0L2IQ
Former ID
DNC000639
Drug Name
Fasidotril
Drug Type
Small molecular drug
Indication Hypotension [ICD9: 458, 796.3; ICD10:I95] Discontinued in Phase 2 [541638], [545632]
Formula
C23H25NO6S
InChI
InChI=1S/C23H25NO6S/c1-15(23(27)28-12-17-6-4-3-5-7-17)24-22(26)19(13-31-16(2)25)10-18-8-9-20-21(11-18)30-14-29-20/h3-9,11,15,19H,10,12-14H2,1-2H3,(H,24,26)/t15-,19+/m0/s1
InChIKey
KKBIUAUSZKGNOA-HNAYVOBHSA-N
CAS Number
CAS 82059-50-5
PubChem Compound ID
5311337
PubChem Substance ID
7980222, 11056446, 14906080, 15256192, 39341026, 50572132, 103338885, 114155856, 123055289, 128393715, 143205921, 178103115, 226432850, 241032623
Target and Pathway
Target(s) Neutral endopeptidase Target Info Modulator
KEGG Pathway Renin-angiotensin system
Hematopoietic cell lineage
Protein digestion and absorption
Alzheimer's disease
NetPath Pathway EGFR1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Reactome Metabolism of Angiotensinogen to Angiotensins
WikiPathways Metabolism of Angiotensinogen to Angiotensins
Primary Focal Segmental Glomerulosclerosis FSGS
Alzheimers Disease
References
Ref 541638(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6501).
Ref 545632Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003997)