TTD | Drug: D0LF0O

Drug General Information
Drug ID	D0LF0O
Former ID	DNC008930
Drug Name	BMS-695735
Drug Type	Small molecular drug
Indication	Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48]		Preclinical	[548135]
Formula	C26H31ClFN7O
Canonical SMILES	CC1=C2C(=CC(=C1)C3CCN(CC3)CCCF)NC(=C4C(=CC=NC4=O)NCCN5C<br />=C(C=N5)Cl)N2
InChI	1S/C26H31ClFN7O/c1-17-13-19(18-4-10-34(11-5-18)9-2-6-28)14-22-24(17)33-25(32-22)23-21(3-7-30-26(23)36)29-8-12-35-16-20(27)15-31-35/h3,7,13-16,18,29,32-33H,2,4-6,8-12H2,1H3/b25-23+
InChIKey	KPIXLYXGTRJJMP-WJTDDFOZSA-N
PubChem Compound ID	16038356
Target and Pathway
Target(s)	Insulin-like growth factor I receptor	Target Info	Inhibitor	[529668]
Target(s)	Basic fibroblast growth factor receptor 1	Target Info	Inhibitor	[529668]
KEGG Pathway	Ras signaling pathway
	Rap1 signaling pathway
	HIF-1 signaling pathway
	FoxO signaling pathway
	Oocyte meiosis
	Endocytosis
	PI3K-Akt signaling pathway
	AMPK signaling pathway
	Focal adhesion
	Adherens junction
	Signaling pathways regulating pluripotency of stem cells
	Long-term depression
	Ovarian steroidogenesis
	Progesterone-mediated oocyte maturation
	Pathways in cancer
	Transcriptional misregulation in cancer
	Proteoglycans in cancer
	Glioma
	Prostate cancer
	Melanomahsa04010:MAPK signaling pathway
	Regulation of actin cytoskeleton
	Melanoma
	Central carbon metabolism in cancer
NetPath Pathway	TCR Signaling Pathway
PANTHER Pathway	Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
	Insulin/IGF pathway-protein kinase B signaling cascadeP00005:Angiogenesis
	FGF signaling pathway
Pathway Interaction Database	Plasma membrane estrogen receptor signaling
	SHP2 signaling
	IGF1 pathway
	Posttranslational regulation of adherens junction stability and dissassembly
	Integrins in angiogenesis
	Stabilization and expansion of the E-cadherin adherens junctionglypican_1pathway:Glypican 1 network
	Syndecan-4-mediated signaling events
	N-cadherin signaling events
	FGF signaling pathway
Reactome	IRS-related events triggered by IGF1R
Reactome	SHC-related events triggered by IGF1R
WikiPathways	Senescence and Autophagy in Cancer
	Insulin Signaling
	Endochondral Ossification
	Focal Adhesion
	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
	Apoptosis
	Signaling Pathways in Glioblastoma
	TSH signaling pathway
	MicroRNAs in cardiomyocyte hypertrophyWP51:Regulation of Actin Cytoskeleton
	MAPK Signaling Pathway
	Mesodermal Commitment Pathway
	Hair Follicle Development: Induction (Part 1 of 3)
	Integrated Pancreatic Cancer Pathway
	Neural Crest Differentiation
	Signaling by FGFR
References
Ref 548135	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022289)
Ref 529668	J Med Chem. 2008 Oct 9;51(19):5897-900. Epub 2008 Sep 3.Discovery and evaluation of 4-(2-(4-chloro-1H-pyrazol-1-yl)ethylamino)-3-(6-(1-(3-fluoropropyl)piperidin-4-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one (BMS-695735), an orally efficacious inhibitor of insulin-like growth factor-1 receptor kinase with broad spectrum in vivo antitumor activity.

Drug Information