TTD | Drug: D0MH0S

Drug General Information
Drug ID	D0MH0S
Former ID	DNC012469
Drug Name	1-(3-Fluoro-pyridin-2-yl)-4-methyl-piperazine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[533509]
Formula	C10H14FN3
Canonical SMILES	CN1CCN(CC1)C2=C(C=CC=N2)F
InChI	1S/C10H14FN3/c1-13-5-7-14(8-6-13)10-9(11)3-2-4-12-10/h2-4H,5-8H2,1H3
InChIKey	KZNJAAWCEFRAPW-UHFFFAOYSA-N
PubChem Compound ID	13298530
Target and Pathway
Target(s)	Alpha-2A adrenergic receptor	Target Info	Inhibitor	[533509]
	Alpha-2B adrenergic receptor	Target Info	Inhibitor	[533509]
	Alpha-1D adrenergic receptor	Target Info	Inhibitor	[533509]
	Alpha-1A adrenergic receptor	Target Info	Inhibitor	[533509]
KEGG Pathway	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Adrenergic signaling in cardiomyocytes
	Vascular smooth muscle contraction
	Salivary secretionhsa04020:Calcium signaling pathway
	AMPK signaling pathway
	Salivary secretion
NetPath Pathway	IL2 Signaling Pathway
PANTHER Pathway	Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathway
Reactome	Adrenoceptors
	Adrenaline signalling through Alpha-2 adrenergic receptor
	Adrenaline,noradrenaline inhibits insulin secretion
	G alpha (i) signalling events
	G alpha (z) signalling events
	Surfactant metabolismR-HSA-390696:Adrenoceptors
	G alpha (z) signalling eventsR-HSA-390696:Adrenoceptors
	G alpha (q) signalling events
	G alpha (12/13) signalling eventsR-HSA-390696:Adrenoceptors
	G alpha (12/13) signalling events
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Platelet Aggregation (Plug Formation)
	Integration of energy metabolism
	GPCR ligand binding
	GPCR downstream signalingWP58:Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR downstream signaling
	GPCRs, OtherWP58:Monoamine GPCRs
	Endothelin Pathways
	AMPK Signaling
References
Ref 533509	J Med Chem. 1984 Sep;27(9):1182-5.Adrenoceptor and tetrabenazine antagonism activities of some pyridinyltetrahydropyridines.
Ref 533509	J Med Chem. 1984 Sep;27(9):1182-5.Adrenoceptor and tetrabenazine antagonism activities of some pyridinyltetrahydropyridines.

Drug Information