Drug Information

Drug General Information
Drug ID
D0O1BN
Former ID
DNC012122
Drug Name
SULFOARECOLINE
Drug Type
Small molecular drug
Indication Discovery agent Investigative [533450]
Formula
C8H13IO2S
Canonical SMILES
COC(=O)C1=CCC[S+](C1)C.[I-]
InChI
1S/C8H13O2S.HI/c1-10-8(9)7-4-3-5-11(2)6-7;/h4H,3,5-6H2,1-2H3;1H/q+1;/p-1
InChIKey
QFIUNAPEEKPWNB-UHFFFAOYSA-M
PubChem Compound ID
45266262
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M1 Target Info Inhibitor [533450]
Muscarinic acetylcholine receptor M2 Target Info Inhibitor [533450]
Muscarinic acetylcholine receptor M3 Target Info Inhibitor [533450]
Muscarinic acetylcholine receptor M4 Target Info Inhibitor [533450]
Muscarinic acetylcholine receptor M5 Target Info Inhibitor [533450]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Cholinergic synapse
Regulation of actin cytoskeletonhsa04020:Calcium signaling pathway
Regulation of actin cytoskeleton
Insulin secretion
Salivary secretion
Gastric acid secretion
Pancreatic secretionhsa04080:Neuroactive ligand-receptor interaction
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
PathWhiz Pathway Muscle/Heart ContractionPW000565:Gastric Acid Production
Reactome Muscarinic acetylcholine receptors
G alpha (q) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
G alpha (i) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
Acetylcholine regulates insulin secretion
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
GPCR ligand binding
GPCR downstream signalingWP706:SIDS Susceptibility Pathways
GPCR downstream signaling
GPCRs, OtherWP58:Monoamine GPCRs
Integration of energy metabolism
GPCR downstream signalingWP58:Monoamine GPCRs
References
Ref 533450J Med Chem. 1988 Jul;31(7):1312-6.Heterocyclic muscarinic agonists. Synthesis and biological activity of some bicyclic sulfonium arecoline bioisosteres.
Ref 533450J Med Chem. 1988 Jul;31(7):1312-6.Heterocyclic muscarinic agonists. Synthesis and biological activity of some bicyclic sulfonium arecoline bioisosteres.