TTD | Drug: D0O6FX

Drug General Information
Drug ID	D0O6FX
Former ID	DNC006322
Drug Name	4,6,7,10-tetramethyl-6H-benzo[c]chromene-3,8-diol
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527966]
Formula	C17H18O3
Canonical SMILES	CC1C2=C(C(=CC(=C2C)O)C)C3=C(O1)C(=C(C=C3)O)C
InChI	1S/C17H18O3/c1-8-7-14(19)9(2)16-11(4)20-17-10(3)13(18)6-5-12(17)15(8)16/h5-7,11,18-19H,1-4H3
InChIKey	NXVCUJCNTBPNSZ-UHFFFAOYSA-N
PubChem Compound ID	10061675
Target and Pathway
Target(s)	Estrogen receptor	Target Info	Inhibitor	[527966]
Target(s)	Estrogen receptor beta	Target Info	Inhibitor	[527966]
KEGG Pathway	Estrogen signaling pathway
	Prolactin signaling pathway
	Thyroid hormone signaling pathway
	Endocrine and other factor-regulated calcium reabsorption
	Proteoglycans in cancerhsa04915:Estrogen signaling pathway
NetPath Pathway	FSH Signaling Pathway
	EGFR1 Signaling Pathway
	RANKL Signaling Pathway
Pathway Interaction Database	Regulation of nuclear SMAD2/3 signaling
	Signaling events mediated by HDAC Class II
	Plasma membrane estrogen receptor signaling
	LKB1 signaling events
	Regulation of Telomerase
	ATF-2 transcription factor network
	AP-1 transcription factor network
	FOXM1 transcription factor network
	Validated nuclear estrogen receptor alpha network
	Signaling mediated by p38-alpha and p38-beta
	FOXA1 transcription factor networker_nongenomic_pathway:Plasma membrane estrogen receptor signaling
	Validated nuclear estrogen receptor beta network
Reactome	Nuclear signaling by ERBB4
Reactome	Nuclear Receptor transcription pathwayR-HSA-383280:Nuclear Receptor transcription pathway
WikiPathways	Estrogen signaling pathway
	Nuclear Receptors Meta-Pathway
	Estrogen Receptor Pathway
	Signaling by ERBB4
	JAK/STAT
	Integrated Pancreatic Cancer Pathway
	Leptin signaling pathway
	miR-targeted genes in muscle cell - TarBase
	Integrated Breast Cancer Pathway
	Nuclear ReceptorsWP706:SIDS Susceptibility Pathways
	Ovarian Infertility Genes
	Nuclear Receptors
References
Ref 527966	Bioorg Med Chem Lett. 2006 Mar 15;16(6):1468-72. Epub 2006 Jan 18.6H-Benzo[c]chromen-6-one derivatives as selective ERbeta agonists.
Ref 527966	Bioorg Med Chem Lett. 2006 Mar 15;16(6):1468-72. Epub 2006 Jan 18.6H-Benzo[c]chromen-6-one derivatives as selective ERbeta agonists.

Drug Information