Drug Information

Drug General Information
Drug ID
D0PO9X
Former ID
DNC007244
Drug Name
2-morpholino-6-(naphthalen-1-yl)-4H-pyran-4-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528738]
Formula
C19H17NO3
Canonical SMILES
C1COCCN1C2=CC(=O)C=C(O2)C3=CC=CC4=CC=CC=C43
InChI
1S/C19H17NO3/c21-15-12-18(23-19(13-15)20-8-10-22-11-9-20)17-7-3-5-14-4-1-2-6-16(14)17/h1-7,12-13H,8-11H2
InChIKey
VSXKSTFHVOSHSV-UHFFFAOYSA-N
PubChem Compound ID
16204046
Target and Pathway
Target(s) DNA-dependent protein kinase catalytic subunit Target Info Inhibitor [528738]
KEGG Pathway Non-homologous end-joining
Cell cycle
NetPath Pathway IL1 Signaling Pathway
Pathway Interaction Database DNA-PK pathway in nonhomologous end joining
Coregulation of Androgen receptor activity
Class I PI3K signaling events mediated by Akt
BARD1 signaling events
Reactome Nonhomologous End-Joining (NHEJ)
WikiPathways DNA Damage Response
Non-homologous end joining
FAS pathway and Stress induction of HSP regulation
Cytosolic sensors of pathogen-associated DNA
Retinoblastoma (RB) in Cancer
Prostate Cancer
Double-Strand Break Repair
Cell Cycle
miRNA Regulation of DNA Damage Response
References
Ref 528738J Med Chem. 2007 Apr 19;50(8):1958-72. Epub 2007 Mar 20.Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
Ref 528738J Med Chem. 2007 Apr 19;50(8):1958-72. Epub 2007 Mar 20.Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.