TTD | Drug: D0Q1ER

Drug General Information
Drug ID	D0Q1ER
Former ID	DNC011782
Drug Name	CGS-12066B
Drug Type	Small molecular drug
Indication	Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42]		Terminated	[538669], [546046]
Formula	C17H17F3N4
InChI	InChI=1S/C17H17F3N4/c1-22-7-9-23(10-8-22)16-15-3-2-6-24(15)14-5-4-12(17(18,19)20)11-13(14)21-16/h2-6,11H,7-10H2,1H3
InChIKey	LXFHSCDLMBZYKY-UHFFFAOYSA-N
PubChem Compound ID	2689
PubChem Substance ID	5658900, 8151746, 11110877, 11113615, 14851157, 24263004, 26751815, 29221846, 47291321, 47291322, 47662508, 50070771, 50104508, 76144594, 85209444, 85787308, 90341822, 103197449, 103927403, 104301319, 124749628, 124879474, 124879475, 124879476, 126407429, 128554479, 131342071, 134348987, 135610867, 135650081, 162220815, 162958006, 179149568, 227848535, 250105533
Target and Pathway
Target(s)	5-hydroxytryptamine 1B receptor	Target Info	Modulator
KEGG Pathway	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Serotonergic synapse
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PANTHER Pathway	5HT1 type receptor mediated signaling pathway
Reactome	Serotonin receptors
Reactome	G alpha (i) signalling events
WikiPathways	Serotonin HTR1 Group and FOS Pathway
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 538669	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 109).
Ref 546046	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006033)

Drug Information