Drug Information

Drug General Information
Drug ID
D0Q8BK
Former ID
DIB019924
Drug Name
GNF-5
Synonyms
GNF5; GNF 5
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530633]
Formula
C20H17F3N4O3
InChI
InChI=1S/C20H17F3N4O3/c21-20(22,23)30-16-6-4-15(5-7-16)27-18-11-17(25-12-26-18)13-2-1-3-14(10-13)19(29)24-8-9-28/h1-7,10-12,28H,8-9H2,(H,24,29)(H,25,26,27)
InChIKey
IIQUYGWWHIHOCF-UHFFFAOYSA-N
PubChem Compound ID
44129660
PubChem Substance ID
85190418, 89927683, 121284525, 123096355, 123107267, 125654123, 142578125, 164045561, 172650411, 176223595, 180371697, 184696698, 196411448, 198955777, 208265428, 210275312, 210280961, 215778581, 223381292, 223624036, 224471999, 226088108, 227186865, 242059845, 246941260, 247667836, 249565745, 249816439, 249867410, 250199120, 251910360, 251966952, 252078797, 252110289, 252158460, 252215482, 252439199, 252451430, 252471825
Target and Pathway
Target(s) mRNA of Abl Target Info Inhibitor [530633]
KEGG Pathway ErbB signaling pathway
Ras signaling pathway
Cell cycle
Axon guidance
Neurotrophin signaling pathway
Pathogenic Escherichia coli infection
Shigellosis
Pathways in cancer
MicroRNAs in cancer
Chronic myeloid leukemia
Viral myocarditis
PANTHER Pathway Axon guidance mediated by Slit/Robo
Pathway Interaction Database p73 transcription factor network
ATM pathway
Regulation of Telomerase
Posttranslational regulation of adherens junction stability and dissassembly
Lissencephaly gene (LIS1) in neuronal migration and development
PDGFR-beta signaling pathway
Neurotrophic factor-mediated Trk receptor signaling
Validated transcriptional targets of TAp63 isoforms
p53 pathway
Regulation of retinoblastoma protein
Reactome Regulation of actin dynamics for phagocytic cup formation
CDO in myogenesis
RHO GTPases Activate WASPs and WAVEs
HDR through Single Strand Annealing (SSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Factors involved in megakaryocyte development and platelet production
WikiPathways DNA Damage Response (only ATM dependent)
DNA Damage Response
ErbB Signaling Pathway
EGF/EGFR Signaling Pathway
Apoptosis-related network due to altered Notch3 in ovarian cancer
Fcgamma receptor (FCGR) dependent phagocytosis
ATM Signaling Pathway
Retinoblastoma (RB) in Cancer
Integrated Pancreatic Cancer Pathway
Pathogenic Escherichia coli infection
Regulation of Microtubule Cytoskeleton
Integrated Breast Cancer Pathway
Signaling by Robo receptor
Myogenesis
Factors involved in megakaryocyte development and platelet production
TP53 Network
miRNAs involved in DNA damage response
miRNA Regulation of DNA Damage Response
References
Ref 530633Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors. Nature. 2010 Jan 28;463(7280):501-6.
Ref 530633Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors. Nature. 2010 Jan 28;463(7280):501-6.