Drug Information

Drug General Information
Drug ID
D0QQ7N
Former ID
DIB011069
Drug Name
TH-9229
Synonyms
Protectazem
Indication Reperfusion injury [ICD10:I00-I99] Terminated [546444]
Company
Theratechnologies Inc
Canonical SMILES
C1(=O)N(c2c(S[C@@H]([C@@H]1O)c1ccc(cc1)OC)cccc2)CCNC
CAS Number
CAS 86408-40-4
Target and Pathway
Target(s) Voltage-dependent P/Q-type calcium channel alpha-1A subunit Target Info Modulator [546445]
Voltage-dependent L-type calcium channel alpha-1D subunit Target Info Modulator [546445]
Voltage-dependent L-type calcium channel subunit alpha-1C Target Info Modulator [546445]
Voltage-dependent R-type calcium channel alpha-1E subunit Target Info Modulator [546445]
Voltage-dependent N-type calcium channel Target Info Modulator [546445]
KEGG Pathway MAPK signaling pathway
Calcium signaling pathway
Synaptic vesicle cycle
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
GABAergic synapse
Dopaminergic synapse
Long-term depression
Taste transduction
Type II diabetes mellitus
Morphine addiction
Nicotine addictionhsa04010:MAPK signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Cardiac muscle contraction
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Circadian entrainment
Insulin secretion
GnRH signaling pathway
Oxytocin signaling pathway
Carbohydrate digestion and absorption
Alzheimer's disease
Amphetamine addiction
Hypertrophic cardiomyopathy (HCM)
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Dilated cardiomyopathyhsa04010:MAPK signaling pathway
Long-term potentiation
Type II diabetes mellitushsa04010:MAPK signaling pathway
Nicotine addiction
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group II pathway
Thyrotropin-releasing hormone receptor signaling pathway
Endogenous cannabinoid signaling
GABA-B receptor II signalingP00003:Alzheimer disease-amyloid secretase pathway
Nicotinic acetylcholine receptor signaling pathway
5HT2 type receptor mediated signaling pathway
Beta1 adrenergic receptor signaling pathway
Beta2 adrenergic receptor signaling pathway
Oxytocin receptor mediated signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
Oxytocin receptor mediated signaling pathway
Nicotine pharmacodynamics pathwayP00027:Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Thyrotropin-releasing hormone receptor signaling pathwayP00027:Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
GABA-B receptor II signaling
PathWhiz Pathway Pancreas FunctionPW000564:Muscle/Heart Contraction
Reactome Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels
Regulation of insulin secretionR-HSA-400042:Adrenaline,noradrenaline inhibits insulin secretion
NCAM1 interactions
Regulation of insulin secretionR-HSA-112308:Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels
WikiPathways Calcium Regulation in the Cardiac Cell
Synaptic Vesicle Pathway
Integration of energy metabolism
Type II diabetes mellitusWP536:Calcium Regulation in the Cardiac Cell
Arrhythmogenic Right Ventricular Cardiomyopathy
Alzheimers Disease
NCAM signaling for neurite out-growth
Integration of energy metabolismWP536:Calcium Regulation in the Cardiac Cell
Nicotine Activity on Chromaffin CellsWP536:Calcium Regulation in the Cardiac Cell
References
Ref 546444Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008159)
Ref 546445Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008159)