Drug Information

Drug General Information
Drug ID
D0R9KG
Former ID
DIB015327
Drug Name
Temanogrel
Synonyms
Temanogrel hydrochloride; APD-791; 5-HT 2a inverse agonist (arterial thrombosis), Arena Pharmaceutical
Drug Type
Small molecular drug
Indication Cardiovascular disorder [ICD10:I00-I99] Phase 1 [524599]
Company
Arena Pharmaceuticals; Arena Pharmaceuticals Inc
Formula
C24H28N4O4
Canonical SMILES
C(=O)(c1cc(ccc1)OC)Nc1cc(c(cc1)OCCN1CCOCC1)c1n(ncc1)C
PubChem Compound ID
11604525
Target and Pathway
Target(s) 5-hydroxytryptamine 2A receptor Target Info Agonist [526792], [550267]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 524599ClinicalTrials.gov (NCT02034292) Safety Study of APD-791 With Aspirin and/or Clopidogrel. U.S. National Institutes of Health.
Ref 526792Pharmacological profile of the new potent neuroleptic ocaperidone (R 79,598). J Pharmacol Exp Ther. 1992 Jan;260(1):146-59.
Ref 550267Clinical pipeline report, company report or official report of Arena Pharmaceuticals.