Drug Information

Drug General Information
Drug ID
D0S5EF
Former ID
DIB014422
Drug Name
PF-4418948
Synonyms
PF-04418948; Prostaglandin E2 EP2 subtype antagonist (endometriosis), Pfizer
Drug Type
Small molecular drug
Indication Endometriosis [ICD9: 617; ICD10:N80] Phase 1 [522833], [541135]
Company
Pfizer Inc
Formula
C23H20FNO5
InChI
InChI=1S/C23H20FNO5/c1-29-19-8-4-17-11-20(9-5-16(17)10-19)30-14-23(22(27)28)12-25(13-23)21(26)15-2-6-18(24)7-3-15/h2-11H,12-14H2,1H3,(H,27,28)
InChIKey
LWJGMYMNSNVCEM-UHFFFAOYSA-N
PubChem Compound ID
25114442
PubChem Substance ID
56438506, 81000929, 141874841, 163643135, 178102442, 198946214, 224220697, 229632422, 241377195, 242645573, 248136620, 249691306, 252158384, 252160663
Target and Pathway
Target(s) Prostaglandin E2receptor, EP2 subtype Target Info Antagonist [550328]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
Renin secretion
Pathways in cancer
Reactome Prostanoid ligand receptors
G alpha (s) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Ovarian Infertility Genes
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 522833ClinicalTrials.gov (NCT01002963) A Study To Investigate The Safety And Toleration Of A Single Dose Of PF-04418948 In Healthy Volunteers. U.S. National Institutes of Health.
Ref 541135(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5817).
Ref 550328Clinical pipeline report, company report or official report of axonmedchem.