Drug General Information
Drug ID
D0T8AJ
Former ID
DNC009659
Drug Name
N-(biphenyl-3-yl)-6-(sulfamoylamino)hexanamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529866]
Formula
C18H23N3O3S
Canonical SMILES
C1=CC=C(C=C1)C2=CC(=CC=C2)NC(=O)CCCCCNS(=O)(=O)N
InChI
1S/C18H23N3O3S/c19-25(23,24)20-13-6-2-5-12-18(22)21-17-11-7-10-16(14-17)15-8-3-1-4-9-15/h1,3-4,7-11,14,20H,2,5-6,12-13H2,(H,21,22)(H2,19,23,24)
InChIKey
XZBFBJMQHOJIMB-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) Histone deacetylase 6 Target Info Inhibitor [529866]
KEGG Pathway Alcoholism
Viral carcinogenesis
Pathway Interaction Database Signaling events mediated by HDAC Class II
Signaling events mediated by HDAC Class I
Reactome NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Assembly of the primary cilium
WikiPathways Ectoderm Differentiation
Neural Crest Differentiation
Cell Cycle
References
Ref 529866Bioorg Med Chem Lett. 2009 Jan 15;19(2):336-40. Epub 2008 Nov 27.Sulfamides as novel histone deacetylase inhibitors.
Ref 529866Bioorg Med Chem Lett. 2009 Jan 15;19(2):336-40. Epub 2008 Nov 27.Sulfamides as novel histone deacetylase inhibitors.