TTD | Drug: D0U8ZQ

Drug General Information
Drug ID	D0U8ZQ
Former ID	DNC013032
Drug Name	Benzyl 4-aminobutyl(3-aminopropyl)carbamate
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528098]
Formula	C15H25N3O2
Canonical SMILES	C1=CC=C(C=C1)COC(=O)N(CCCCN)CCCN
InChI	1S/C15H25N3O2/c16-9-4-5-11-18(12-6-10-17)15(19)20-13-14-7-2-1-3-8-14/h1-3,7-8H,4-6,9-13,16-17H2
InChIKey	ADDDUQKJZAGBIG-UHFFFAOYSA-N
PubChem Compound ID	389610
Target and Pathway
Target(s)	NMDA receptor subunit NR1	Target Info	Inhibitor	[528098]
	Glutamate [NMDA] receptor subunit epsilon 1	Target Info	Inhibitor	[528098]
	Glutamate [NMDA] receptor subunit epsilon 2	Target Info	Inhibitor	[528098]
KEGG Pathway	Ras signaling pathway
	Rap1 signaling pathway
	Calcium signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Circadian entrainment
	Long-term potentiation
	Glutamatergic synapse
	Alzheimer's disease
	Amyotrophic lateral sclerosis (ALS)
	Huntington's disease
	Cocaine addiction
	Amphetamine addiction
	Nicotine addiction
	Alcoholismhsa04014:Ras signaling pathway
	Dopaminergic synapse
	Alcoholism
	Systemic lupus erythematosushsa04014:Ras signaling pathway
	Systemic lupus erythematosus
PANTHER Pathway	Huntington disease
	Ionotropic glutamate receptor pathway
	Metabotropic glutamate receptor group III pathway
	Metabotropic glutamate receptor group I pathway
	Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00029:Huntington disease
	Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Pathway Interaction Database	Reelin signaling pathwayerbb4_pathway:ErbB4 signaling events
Pathway Interaction Database	Reelin signaling pathway
Reactome	EPHB-mediated forward signaling
	Unblocking of NMDA receptor, glutamate binding and activation
	CREB phosphorylation through the activation of CaMKII
	Ras activation uopn Ca2+ infux through NMDA receptor
	RAF/MAP kinase cascadeR-HSA-438066:Unblocking of NMDA receptor, glutamate binding and activation
	RAF/MAP kinase cascadeR-HSA-3928662:EPHB-mediated forward signaling
	RAF/MAP kinase cascade
WikiPathways	SIDS Susceptibility Pathways
	Hypothetical Network for Drug Addiction
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Spinal Cord Injury
	BDNF signaling pathway
	Alzheimers DiseaseWP666:Hypothetical Network for Drug Addiction
References
Ref 528098	Bioorg Med Chem Lett. 2006 Jun 1;16(11):2837-41. Epub 2006 Mar 24.Polyamines and the NMDA receptor: modifying intrinsic activities with aromatic substituents.
Ref 528098	Bioorg Med Chem Lett. 2006 Jun 1;16(11):2837-41. Epub 2006 Mar 24.Polyamines and the NMDA receptor: modifying intrinsic activities with aromatic substituents.

Drug Information