Drug Information

Drug General Information
Drug ID
D0US9O
Former ID
DIB019301
Drug Name
compound 19a
Drug Type
Small molecular drug
Indication Discovery agent Investigative [532598]
Formula
C16H16FN9
InChI
InChI=1S/C16H16FN9/c1-9(13-19-5-10(17)6-20-13)22-16-24-14-11(3-4-18-14)15(25-16)23-12-7-26(2)8-21-12/h3-9H,1-2H3,(H3,18,22,23,24,25)/t9-/m0/s1
InChIKey
QHXBWJSQXSYAGG-VIFPVBQESA-N
PubChem Compound ID
45275255
PubChem Substance ID
92757658, 120273956, 178103556, 194188146, 194944878, 224523221, 237443765
Target and Pathway
Target(s) Tyrosine-protein kinase JAK2 Target Info Inhibitor [532598]
JAK1 Target Info Inhibitor [532598]
Tyrosine-protein kinase JAK3 Target Info Inhibitor [532598]
KEGG Pathway Chemokine signaling pathway
PI3K-Akt signaling pathway
Signaling pathways regulating pluripotency of stem cells
Jak-STAT signaling pathway
Cholinergic synapse
Prolactin signaling pathway
Adipocytokine signaling pathway
Leishmaniasis
Toxoplasmosis
Tuberculosis
Measles
Influenza A
Herpes simplex infectionhsa04151:PI3K-Akt signaling pathway
Osteoclast differentiation
Hepatitis C
Hepatitis B
HTLV-I infection
Herpes simplex infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Pancreatic cancerhsa04062:Chemokine signaling pathway
Primary immunodeficiency
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Interferon-gamma signaling pathway
JAK/STAT signaling pathway
PDGF signaling pathway
PI3 kinase pathway
CCKR signaling map STP00005:Angiogenesis
PDGF signaling pathwayP00036:Interleukin signaling pathway
Pathway Interaction Database Endothelins
ErbB4 signaling events
GMCSF-mediated signaling events
IL4-mediated signaling events
IL27-mediated signaling events
Signaling events mediated by PTP1B
IL12-mediated signaling events
S1P3 pathway
SHP2 signaling
CXCR4-mediated signaling events
IL5-mediated signaling events
IFN-gamma pathway
ErbB2/ErbB3 signaling events
IL3-mediated signaling events
IL6-mediated signaling events
PDGFR-beta signaling pathway
IL23-mediated signaling events
Signaling events mediated by Stem cell factor receptor (c-Kit)
EPO signaling pathway
Notch-mediated HES/HEY networkp73pathway:p73 transcription factor network
Signaling events mediated by TCPTP
IL2-mediated signaling events
IL2 signaling events mediated by PI3K
PDGFR-alpha signaling pathway
IL2 signaling events mediated by STAT5il4_2pathway:IL4-mediated signaling events
CD40/CD40L signaling
IL2 signaling events mediated by STAT5
Reactome Interleukin-6 signaling
MAPK3 (ERK1) activation
MAPK1 (ERK2) activation
GPVI-mediated activation cascade
Prolactin receptor signaling
RMTs methylate histone arginines
G beta:gamma signalling through PI3Kgamma
Interleukin-3, 5 and GM-CSF signaling
RAF activation
RAF/MAP kinase cascade
Interferon gamma signaling
Regulation of IFNG signaling
Interleukin receptor SHC signaling
Growth hormone receptor signaling
Factors involved in megakaryocyte development and platelet productionR-HSA-1059683:Interleukin-6 signaling
ISG15 antiviral mechanism
Interleukin-7 signaling
Interleukin-2 signaling
Interferon alpha/beta signaling
Regulation of IFNA signalingR-HSA-114604:GPVI-mediated activation cascade
WikiPathways Serotonin Receptor 2 and STAT3 Signaling
Type II interferon signaling (IFNG)
Notch Signaling Pathway
EPO Receptor Signaling
EGF/EGFR Signaling Pathway
IL-4 Signaling Pathway
IL-6 signaling pathway
Kit receptor signaling pathway
IL-3 Signaling Pathway
Mesodermal Commitment Pathway
Interleukin-2 signaling
Signaling by SCF-KIT
Prolactin receptor signaling
Growth hormone receptor signaling
JAK/STAT
BDNF signaling pathway
Oncostatin M Signaling Pathway
Interleukin-11 Signaling Pathway
AGE/RAGE pathway
TSLP Signaling Pathway
IL17 signaling pathway
Leptin signaling pathway
TSH signaling pathway
Interleukin-3, 5 and GM-CSF signaling
Interferon gamma signaling
Factors involved in megakaryocyte development and platelet production
IL-5 Signaling PathwayWP619:Type II interferon signaling (IFNG)
Interferon type I signaling pathways
TGF Beta Signaling Pathway
IL-2 Signaling Pathway
TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer
Interleukin-7 signaling
PDGF Pathway
Prostate Cancer
IL-9 Signaling Pathway
Type III interferon signaling
IL-7 Signaling Pathway
Integrated Breast Cancer Pathway
Integrated Cancer pathway
Interferon alpha/beta signaling
IL-5 Signaling PathwayWP49:IL-2 Signaling Pathway
References
Ref 532598Discovery of 1-methyl-1H-imidazole derivatives as potent Jak2 inhibitors. J Med Chem. 2014 Jan 9;57(1):144-58.
Ref 532598Discovery of 1-methyl-1H-imidazole derivatives as potent Jak2 inhibitors. J Med Chem. 2014 Jan 9;57(1):144-58.