Drug Information

Drug General Information
Drug ID
D0W3GL
Former ID
DNC005420
Drug Name
SR-147778
Drug Type
Small molecular drug
Indication Obesity [ICD9: 278; ICD10:E66] Phase 2 [521745]
Formula
C23H23BrCl2N4O
Canonical SMILES
CCC1=C(N(N=C1C(=O)NN2CCCCC2)C3=C(C=C(C=C3)Cl)Cl)C4=CC=C<br />(C=C4)Br
InChI
1S/C23H23BrCl2N4O/c1-2-18-21(23(31)28-29-12-4-3-5-13-29)27-30(20-11-10-17(25)14-19(20)26)22(18)15-6-8-16(24)9-7-15/h6-11,14H,2-5,12-13H2,1H3,(H,28,31)
InChIKey
HMXDWDSNPRNUKI-UHFFFAOYSA-N
PubChem Compound ID
9849616
Target and Pathway
Target(s) Cannabinoid receptor 1 Target Info Modulator
KEGG Pathway Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
PANTHER Pathway Endogenous cannabinoid signaling
Pathway Interaction Database N-cadherin signaling events
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
BDNF signaling pathway
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 521745ClinicalTrials.gov (NCT00239174) A Multicenter Study to Evaluate the Efficacy and Safety of of Four Doses of SR147778 in Obese Patients. U.S. National Institutes of Health.