Drug Information

Drug General Information
Drug ID
D0Y8DT
Former ID
DIB020810
Drug Name
Glycyl-H 1152
Synonyms
glycyl-H 1152
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527785]
Formula
C18H24N4O3S
InChI
InChI=1S/C18H24N4O3S/c1-13-10-20-11-15-5-3-6-16(18(13)15)26(24,25)22-8-4-7-21(12-14(22)2)17(23)9-19/h3,5-6,10-11,14H,4,7-9,12,19H2,1-2H3/t14-/m0/s1
InChIKey
CMKMGFAUKPAOMG-AWEZNQCLSA-N
PubChem Compound ID
11976582
PubChem Substance ID
17428643, 24491552, 36472792, 75778357, 138508531, 162263953, 174006415, 178102655, 180438589, 226973253, 242585890, 247677732
Target and Pathway
Target(s) Rho associated protein kinase 2 Target Info Inhibitor [527785]
Aurora protein kinase Target Info Inhibitor [527785]
KEGG Pathway cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
Sphingolipid signaling pathway
Vascular smooth muscle contraction
Wnt signaling pathway
Axon guidance
Focal adhesion
Platelet activation
Leukocyte transendothelial migration
Regulation of actin cytoskeleton
Oxytocin signaling pathway
Pathogenic Escherichia coli infection
Shigellosis
Salmonella infection
Pathways in cancer
Proteoglycans in cancerhsa04114:Oocyte meiosis
PANTHER Pathway Cytoskeletal regulation by Rho GTPase
Pathway Interaction Database RhoA signaling pathway
Plasma membrane estrogen receptor signaling
Osteopontin-mediated events
PLK1 signaling events
PAR4-mediated thrombin signaling events
PAR1-mediated thrombin signaling events
Signaling events mediated by focal adhesion kinase
Reactome EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
G alpha (12/13) signalling events
Sema4D induced cell migration and growth-cone collapse
VEGFA-VEGFR2 Pathway
RHO GTPases Activate ROCKsR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
WikiPathways G13 Signaling Pathway
Regulation of Actin Cytoskeleton
Focal Adhesion
JAK/STAT
Spinal Cord Injury
Pathogenic Escherichia coli infection
Leptin signaling pathway
Semaphorin interactions
Integrin-mediated Cell Adhesion
GPCR downstream signaling
MicroRNAs in cardiomyocyte hypertrophy
Androgen receptor signaling pathwayWP437:EGF/EGFR Signaling Pathway
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteins
References
Ref 527785Development of specific Rho-kinase inhibitors and their clinical application. Biochim Biophys Acta. 2005 Dec 30;1754(1-2):245-52. Epub 2005 Sep 12.
Ref 527785Development of specific Rho-kinase inhibitors and their clinical application. Biochim Biophys Acta. 2005 Dec 30;1754(1-2):245-52. Epub 2005 Sep 12.