Drug General Information
Drug ID
D0YB9P
Former ID
DNC004364
Drug Name
GLUTAMATE
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528723]
Structure
Download

3D MOL

Formula
C5H9NO4
Canonical SMILES
C(CC(=O)O)C(C(=O)O)N
InChI
1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1
InChIKey
WHUUTDBJXJRKMK-GSVOUGTGSA-N
PubChem Compound ID
Target and Pathway
Target(s) Metabotropic glutamate receptor 2 Target Info Inhibitor [529001]
Metabotropic glutamate receptor 8 Target Info Inhibitor [528723]
Metabotropicglutamate receptor 1 Target Info Inhibitor [529001]
Glutamate receptor, ionotropic kainate 1 Target Info Inhibitor [530863]
NMDA receptor subunit NR1 Target Info Inhibitor [526787]
Metabotropic glutamate receptor 5 Target Info Inhibitor [529001]
Glutamate [NMDA] receptor subunit epsilon 2 Target Info Inhibitor [526787]
Adenosine A3 receptor Target Info Inhibitor [527823]
Glutamate receptor 1 Target Info Inhibitor [529714]
Glutamate [NMDA] receptor subunit epsilon 1 Target Info Inhibitor [526787]
Glutamate receptor AMPA subtype Target Info Inhibitor [530863]
Metabotropic glutamate receptor 4 Target Info Inhibitor [528723]
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapse
Cocaine addictionhsa04080:Neuroactive ligand-receptor interaction
Glutamatergic synapsehsa04020:Calcium signaling pathway
FoxO signaling pathway
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Long-term depression
Estrogen signaling pathwayhsa04080:Neuroactive ligand-receptor interaction
Glutamatergic synapsehsa04014:Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
cAMP signaling pathway
Circadian entrainment
Alzheimer's disease
Amyotrophic lateral sclerosis (ALS)
Huntington's disease
Cocaine addiction
Amphetamine addiction
Nicotine addiction
Alcoholismhsa04020:Calcium signaling pathway
Huntington's diseasehsa04014:Ras signaling pathway
Dopaminergic synapse
Alcoholism
Systemic lupus erythematosushsa04024:cAMP signaling pathway
Nicotine addictionhsa04014:Ras signaling pathway
Systemic lupus erythematosushsa04080:Neuroactive ligand-receptor interaction
Taste transduction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group II pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Metabotropic glutamate receptor group III pathwayP00027:Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signalingP00029:Huntington disease
Metabotropic glutamate receptor group I pathwayP00029:Huntington disease
Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00027:Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00037:Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group III pathwayP00029:Huntington disease
Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Pathway Interaction Database ErbB4 signaling events
Reelin signaling pathwayephbfwdpathway:EPHB forward signalingreelinpathway:Reelin signaling pathway
Reactome G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)R-HSA-418594:G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)R-HSA-416476:G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)R-HSA-3928662:EPHB-mediated forward signaling
Unblocking of NMDA receptor, glutamate binding and activation
CREB phosphorylation through the activation of CaMKII
Ras activation uopn Ca2+ infux through NMDA receptor
RAF/MAP kinase cascadeR-HSA-416476:G alpha (q) signalling events
RAF/MAP kinase cascadeR-HSA-417973:Adenosine P1 receptors
G alpha (i) signalling eventsR-HSA-204005:COPII (Coat Protein 2) Mediated Vesicle Transport
Trafficking of AMPA receptors
Trafficking of GluR2-containing AMPA receptors
Cargo concentration in the ERR-HSA-438066:Unblocking of NMDA receptor, glutamate binding and activation
RAF/MAP kinase cascadeR-HSA-418594:G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
GPCR ligand binding
GPCR downstream signalingWP501:GPCRs, Class C Metabotropic glutamate, pheromone
GPCR downstream signaling
GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
Gastrin-CREB signalling pathway via PKC and MAPK
GPCRs, OtherWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellWP706:SIDS Susceptibility Pathways
Hypothetical Network for Drug Addiction
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Spinal Cord Injury
BDNF signaling pathway
Alzheimers DiseaseWP666:Hypothetical Network for Drug Addiction
GPCR downstream signalingWP666:Hypothetical Network for Drug Addiction
BDNF signaling pathwayWP80:Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
Amyotrophic lateral sclerosis (ALS)
BDNF signaling pathwayWP666:Hypothetical Network for Drug Addiction
Alzheimers DiseaseWP501:GPCRs, Class C Metabotropic glutamate, pheromone
References
Ref 528723Bioorg Med Chem. 2007 May 1;15(9):3161-70. Epub 2007 Feb 22.Synthesis and preliminary pharmacological evaluation of the four stereoisomers of (2S)-2-(2'-phosphono-3'-phenylcyclopropyl)glycine, the first class of 3'-substituted trans C1'-2'-2-(2'-phosphonocyclopropyl)glycines.
Ref 526787J Med Chem. 1992 Dec 11;35(25):4720-6.Bioisosteric replacement of the alpha-amino carboxylic acid functionality in 2-amino-5-phosphonopentanoic acid yields unique 3,4-diamino-3-cyclobutene-1,2-dione containing NMDA antagonists.
Ref 527823J Med Chem. 2005 Nov 3;48(22):6887-96.2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization.
Ref 528723Bioorg Med Chem. 2007 May 1;15(9):3161-70. Epub 2007 Feb 22.Synthesis and preliminary pharmacological evaluation of the four stereoisomers of (2S)-2-(2'-phosphono-3'-phenylcyclopropyl)glycine, the first class of 3'-substituted trans C1'-2'-2-(2'-phosphonocyclopropyl)glycines.
Ref 529001J Med Chem. 2007 Sep 20;50(19):4630-41. Epub 2007 Aug 29.Synthesis, molecular modeling studies, and preliminary pharmacological characterization of all possible 2-(2'-sulfonocyclopropyl)glycine stereoisomers as conformationally constrained L-homocysteic acid analogs.
Ref 529714J Med Chem. 2008 Oct 23;51(20):6614-8. Epub 2008 Sep 24.1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. structure-activity relationships and identification of potent and Selective iGluR5 modulators.
Ref 530863J Med Chem. 2010 May 27;53(10):4110-8.4-hydroxy-1,2,5-oxadiazol-3-yl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and molecular pharmacological characterization at ionotropic glutamate receptors of compounds related to glutamate and its homologues.