Drug Information

Drug General Information
Drug ID
D0YP7L
Former ID
DNC003585
Drug Name
SB-269970
Drug Type
Small molecular drug
Indication Sleep disorders [ICD9: 307.4, 327, 780.5; ICD10:F51, G47] Terminated [540209], [547602]
Formula
C18H28N2O3S
InChI
InChI=1S/C18H28N2O3S/c1-15-7-11-19(12-8-15)13-9-16-4-3-10-20(16)24(22,23)18-6-2-5-17(21)14-18/h2,5-6,14-16,21H,3-4,7-13H2,1H3/t16-/m1/s1
InChIKey
HWKROQUZSKPIKQ-MRXNPFEDSA-N
PubChem Compound ID
6604889
PubChem Substance ID
11114150, 11646537, 14827849, 14852068, 43224626, 47944892, 50104910, 77543877, 90340608, 103197548, 103995564, 114638177, 124750207, 134221723, 134340790, 135261782, 136367793, 137955553, 142785885, 172919549, 178100289, 178100296, 210275223, 210280862, 223394130, 223556755, 223702874, 226707028, 241383851, 242176196, 246475623, 249615589, 249855013, 250225791, 251971167, 252074169, 252212987, 252434592, 252474530
Target and Pathway
Target(s) 5-hydroxytryptamine 7 receptor Target Info Modulator
KEGG Pathway Ras signaling pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 7 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 540209(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3233).
Ref 547602Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017732)