Drug Information

Drug General Information
Drug ID
D0YZ8G
Former ID
DNC014348
Drug Name
5-Chloro-2-(2-methylquinolin-7-yl)benzonitrile
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530843]
Formula
C17H11ClN2
Canonical SMILES
CC1=NC2=C(C=C1)C=CC(=C2)C3=C(C=C(C=C3)Cl)C#N
InChI
1S/C17H11ClN2/c1-11-2-3-12-4-5-13(9-17(12)20-11)16-7-6-15(18)8-14(16)10-19/h2-9H,1H3
InChIKey
BYFVDRQULSVRKZ-UHFFFAOYSA-N
PubChem Compound ID
46888044
Target and Pathway
Target(s) Metabotropic glutamate receptor 5 Target Info Inhibitor [530843]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 530843Bioorg Med Chem. 2010 May 1;18(9):3026-35. Epub 2010 Mar 27.Structure-activity relationships in a novel series of 7-substituted-aryl quinolines and 5-substituted-aryl benzothiazoles at the metabotropic glutamate receptor subtype 5.
Ref 530843Bioorg Med Chem. 2010 May 1;18(9):3026-35. Epub 2010 Mar 27.Structure-activity relationships in a novel series of 7-substituted-aryl quinolines and 5-substituted-aryl benzothiazoles at the metabotropic glutamate receptor subtype 5.