Drug General Information
Drug ID
D0Z2PJ
Former ID
DNC010537
Drug Name
4-Benzyloxybenzo[b]thiophene-2-carboxamidine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530682]
Formula
C16H14N2OS
Canonical SMILES
C1=CC=C(C=C1)COC2=C3C=C(SC3=CC=C2)C(=N)N
InChI
1S/C16H14N2OS/c17-16(18)15-9-12-13(7-4-8-14(12)20-15)19-10-11-5-2-1-3-6-11/h1-9H,10H2,(H3,17,18)
InChIKey
BMADCBRXHDOABZ-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) Coagulation factor IX Target Info Inhibitor [530682]
KEGG Pathway Complement and coagulation cascades
PANTHER Pathway Blood coagulation
PathWhiz Pathway Coagulation
Reactome Extrinsic Pathway of Fibrin Clot Formation
Intrinsic Pathway of Fibrin Clot Formation
Gamma-carboxylation of protein precursors
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
Removal of aminoterminal propeptides from gamma-carboxylated proteins
WikiPathways Complement and Coagulation Cascades
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
Blood Clotting Cascade
Formation of Fibrin Clot (Clotting Cascade)
References
Ref 530682J Med Chem. 2010 Feb 25;53(4):1465-72.Studies of benzothiophene template as potent factor IXa (FIXa) inhibitors in thrombosis.
Ref 530682J Med Chem. 2010 Feb 25;53(4):1465-72.Studies of benzothiophene template as potent factor IXa (FIXa) inhibitors in thrombosis.