Resistance mutation info of target

Target General Information
Target ID T12355
Target Name G1/S-specific cyclin D1 (CCND1) Target Info
Gene Name CCND1
Species Homo sapiens
Uniprot ID CCND1_HUMAN
Sequence MEHQLLCCEVETIRRAYPDANLLNDRVLRAMLKAEETCAPSVSYFKCVQKEVLPSMRKIV
ATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPVKKSRLQLLGATCMFVASKMKETIPLT
AEKLCIYTDNSIRPEELLQMELLLVNKLKWNLAAMTPHDFIEHFLSKMPEAEENKQIIRK
HAQTFVALCATDVKFISNPPSMVAAGSVVAAVQGLNLRSPNNFLSYYRLTRFLSRVIKCD
PDCLRACQEQIEALLESSLRQAQQNMDPKAAEEEEEEEEEVDLACTPTDVRDVDI [Hom
o sapiens]
Drug Resistance Mutation and Corresponding Drugs
Mutation Info Missense: C47S
Mutation Info Missense: T286A
Mutation Info Missense: Y44D
Reference
Ref 1559235CCND1 mutations increase protein stability and promote ibrutinib resistance in mantle cell lymphoma.Oncotarget.2016 Nov 8;7(45):73558-73572.