Resistance mutation info of target

Target General Information
Target ID T13852
Target Name Sphingosine 1-phosphate receptor 1 (S1PR1) Target Info
Gene Name S1PR1
Species Homo sapiens
Uniprot ID S1PR1_HUMAN
Sequence MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIM
GWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKN
ISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLA
VLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSH
PQKDEGDNPETIMSSGNVNSSS [Homo sapiens]
Drug Resistance Mutation and Corresponding Drugs
Mutation Info Missense: G305C
Mutation Info Missense: I45T
Reference
Ref 1559255Individual variation of human S1P?coding sequence leads to heterogeneity in receptor function and drug interactions.J Lipid Res.2014 Dec;55(12):2665-75.