Resistance mutation info of target

Target General Information
Target ID T40696
Target Name Bacterial DNA topoisomerase 4 subunit A (parC) Target Info
Gene Name parC
Species Escherichia coli
Uniprot ID PARC_ECOLI
Sequence MSDMAERLALHEFTENAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNASAKF
KKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRY
TESRLSKYSELLLSELGQGTADWVPNFDGTLQEPKMLPARLPNILLNGTTGIAVGMATDI
PPHNLREVAQAAIALIDQPKTTLDQLLDIVQGPDYPTEAEIITSRAEIRKIYENGRGSVR
MRAVWKKEDGAVVISALPHQVSGARVLEQIAAQMRNKKLPMVDDLRDESDHENPTRLVIV
PRSNRVDMDQVMNHLFATTDLEKSYRINLNMIGLDGRPAVKNLLEILSEWLVFRRDTVRR
RLNYRLEKVLKRLHILEGLLVAFLNIDEVIEIIRNEDEPKPALMSRFGLTETQAEAILEL
KLRHLAKLEEMKIRGEQSELEKERDQLQGILASERKMNNLLKKELQADAQAYGDDRRSPL
QEREEAKAMSEHDMLPSEPVTIVLSQMGWVRSAKGHDIDAPGLNYKAGDSFKAAVKGKSN
QPVVFVDSTGRSYAIDPITLPSARGQGEPLTGKLTLPPGATVDHMLMESDDQKLLMASDA
GYGFVCTFNDLVARNRAGKALITLPENAHVMPPVVIEDASDMLLAITQAGRMLMFPVSDL
PQLSKGKGNKIINIPSAEAARGEDGLAQLYVLPPQSTLTIHVGKRKIKLRPEELQKVTGE
RGRRGTLMRGLQRIDRVEIDSPRRASSGDSEE [Escherichia coli]
Drug Resistance Mutation and Corresponding Drugs
Mutation Info Missense: A85T
Mutation Info Missense: D111H
Mutation Info Missense: E84G
Mutation Info Missense: E87Q
Mutation Info Missense: E91G
Mutation Info Missense: S129P
Mutation Info Missense: S80I
Mutation Info Missense: S83L
Mutation Info Missense: S83W
Mutation Info Missense: S84F
Mutation Info Missense: S84P
Mutation Info Missense: S87R
Mutation Info Missense: W106G
Reference
Ref 556229The comprehensive antibiotic resistance database. Antimicrob Agents Chemother. 2013 Jul;57(7):3348-57. doi: 10.1128/AAC.00419-13. Epub 2013 May 6.
Ref 556243CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database. Nucleic Acids Res. 2017 Jan 4;45(D1):D566-D573. doi: 10.1093/nar/gkw1004. Epub 2016 Oct 26.
Ref 1559231Antibacterial Resistance in Ureaplasma species and Mycoplasma hominis Isolates from Urine Cultures in College-aged Females.Antimicrob Agents Chemother.2017 Aug 21.