Resistance mutation info of target

Target General Information
Target ID T88240
Target Name Bacterial Hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase (DHPS) Target Info
Gene Name folP
Species Escherichia coli
Uniprot ID DHPS_ECOLI
Sequence MKLFAQGTSLDLSHPHVMGILNVTPDSFSDGGTHNSLIDAVKHANLMINAGATIIDVGGE
STRPGAAEVSVEEELQRVIPVVEAIAQRFEVWISVDTSKPEVIRESAKVGAHIINDIRSL
SEPGALEAAAETGLPVCLMHMQGNPKTMQEAPKYDDVFAEVNRYFIEQIARCEQAGIAKE
KLLLDPGFGFGKNLSHNYSLLARLAEFHHFNLPLLVGMSRKSMIGQLLNVGPSERLSGSL
ACAVIAAMQGAHIIRVHDVKETVEAMRVVEATLSAKENKRYE [Escherichia coli
]
Drug Resistance Mutation and Corresponding Drugs
Mutation Info Missense: A587V
Mutation Info Missense: F25I
Mutation Info Missense: K540E
Mutation Info Missense: K540N
Mutation Info Missense: P55A
Mutation Info Missense: P55H
Mutation Info Missense: P55L
Mutation Info Missense: P55R
Mutation Info Missense: P55S
Mutation Info Missense: P55T
Mutation Info Missense: P64A
Mutation Info Missense: P64H
Mutation Info Missense: P64L
Mutation Info Missense: P64R
Mutation Info Missense: P64S
Mutation Info Missense: T53A
Mutation Info Missense: T53I
Mutation Info Missense: T53N
Mutation Info Missense: T53P
Reference
Ref 555650In vitro susceptibility of various genotypic strains of Toxoplasma gondii to pyrimethamine, sulfadiazine, and atovaquone. Antimicrob Agents Chemother. 2008 Apr;52(4):1269-77. doi: 10.1128/AAC.01203-07. Epub 2008 Jan 22.
Ref 555795Novel K540N mutation in Plasmodium falciparum dihydropteroate synthetase confers a lower level of sulfa drug resistance than does a K540E mutation. Antimicrob Agents Chemother. 2011 May;55(5):2481-2. doi: 10.1128/AAC.01394-10. Epub 2011 Feb 22.
Ref 556229The comprehensive antibiotic resistance database. Antimicrob Agents Chemother. 2013 Jul;57(7):3348-57. doi: 10.1128/AAC.00419-13. Epub 2013 May 6.
Ref 556243CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database. Nucleic Acids Res. 2017 Jan 4;45(D1):D566-D573. doi: 10.1093/nar/gkw1004. Epub 2016 Oct 26.