Target Information

Target General Infomation
Target ID
T39610
Former ID
TTDS00432
Target Name
Calmodulin
Synonyms
CALM2; CaM
Target Type
Successful
Disease Cardiac arrhythmias [ICD9: 427; ICD10: I47-I49]
Malaria [ICD10: B54]
Schizophrenia; Generalized non-psychotic anxiety [ICD10: F20]
Function
Calmodulin mediates the control of a largenumber of enzymes by ca(2+). Among the enzymes to be stimulated by the calmodulin-ca(2+) complex are a number of protein kinases and phosphatases.
BioChemical Class
Calmodulin-dependent secretion
Target Validation
T39610
UniProt ID
P62158
Sequence
MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG
NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE
EVDEMIREADIDGDGQVNYEEFVQMMTAK
Drugs and Mode of Action
Drug(s) Aprindine Drug Info Approved Cardiac arrhythmias [536036]
Halofantrine Drug Info Approved Malaria [538542]
Trifluoperazine Drug Info Approved Schizophrenia; Generalized non-psychotic anxiety [551871]
Inhibitor 2-Methyl-2,4-Pentanediol Drug Info [551393]
2-Methyl-2-Propanol Drug Info [551393]
Acetate Ion Drug Info [551393]
Aprindine Drug Info [537785]
Cacodylate Ion Drug Info [551393]
MYRISTIC ACID Drug Info [551374]
N-Trimethyllysine Drug Info [551393]
Trifluoperazine Drug Info [535849]
Modulator Halofantrine Drug Info [556264]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Phosphatidylinositol signaling system
Oocyte meiosis
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Circadian entrainment
Long-term potentiation
Neurotrophin signaling pathway
Dopaminergic synapse
Olfactory transduction
Phototransduction
Inflammatory mediator regulation of TRP channels
Insulin signaling pathway
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Oxytocin signaling pathway
Glucagon signaling pathway
Salivary secretion
Gastric acid secretion
Alzheimer&#039
s disease
Amphetamine addiction
Alcoholism
Pertussis
Tuberculosis
Glioma
NetPath Pathway RANKL Signaling Pathway
TSH Signaling Pathway
PANTHER Pathway CCKR signaling map ST
Pathway Interaction Database BCR signaling pathway
p38 MAPK signaling pathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Role of Calcineurin-dependent NFAT signaling in lymphocytes
IL2 signaling events mediated by PI3K
IFN-gamma pathway
Lissencephaly gene (LIS1) in neuronal migration and development
ErbB1 downstream signaling
VEGFR1 specific signals
Regulation of cytoplasmic and nuclear SMAD2/3 signaling
Calcium signaling in the CD4+ TCR pathway
Signaling events mediated by VEGFR1 and VEGFR2
Insulin-mediated glucose transport
N-cadherin signaling events
Cellular roles of Anthrax toxin
Regulation of Ras family activation
Downstream signaling in na&amp
#xef
ve CD8+ T cells
PathWhiz Pathway Muscle/Heart Contraction
Reactome Calmodulin induced events
Platelet degranulation
Translocation of GLUT4 to the plasma membrane
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
DARPP-32 events
eNOS activation
Inactivation, recovery and regulation of the phototransduction cascade
FCERI mediated Ca+2 mobilization
Ca2+ pathway
CREB phosphorylation through the activation of CaMKII
Ras activation uopn Ca2+ infux through NMDA receptor
Smooth Muscle Contraction
VEGFR2 mediated vascular permeability
VEGFR2 mediated cell proliferation
RHO GTPases activate IQGAPs
RAF/MAP kinase cascade
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
WikiPathways Translocation of GLUT4 to the Plasma Membrane
Visual phototransduction
Fc epsilon receptor (FCERI) signaling
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Signaling by the B Cell Receptor (BCR)
Inositol phosphate metabolism
DAG and IP3 signaling
Opioid Signalling
Muscle contraction
Metabolism of nitric oxide
Metabolism of carbohydrates
References
Ref 536036Appropriate dosing of antiarrhythmic drugs in Japan requires therapeutic drug monitoring. J Clin Pharm Ther. 2005 Feb;30(1):5-12.
Ref 538542FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 020250.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 535849Inhibitory effect of jujuboside A on glutamate-mediated excitatory signal pathway in hippocampus. Planta Med. 2003 Aug;69(8):692-5.
Ref 537785Aprindine inhibits calmodulin-stimulated phosphodiesterase and Ca-ATPase activities. J Cardiovasc Pharmacol. 1983 Jan-Feb;5(1):151-6.
Ref 551374The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017